The Low-Coste Innovation Blog welcomes YOU

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". My name's Catherine Coste. I've earned myself two MIT digital diplomas: 7.00x and 7QBWx. Instructor: Eric Lander PhD.

My motto: Go Where You Are Celebrated, Not Where You Are Tolerated.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Appel à témoignage - Please share your experience - Teilen Sie Ihre Erfahrungen mit ! Don d'organes - Organ Donation - Organspende :

Appel à témoignage : lettre ouverte aux proches confrontés à la question du don d'organes (lire)

Please share your experience : letter to the attention of next-of-kin of donor-eligible individuals (read)

Im Krankenhaus oder in der Klinik wurden Sie nach dem mutmasslichen Willen Ihres Verwandten gefragt : ob er oder sie sich für Organspende ausgesprochen habe. Bitte teilen Sie Ihre Erfahrung mit ! (lesen)

Avertissement :

Merci de ne PAS poster de messages concernant la vente d'un organe et comportant des coordonnées téléphoniques, e-mail, etc. La loi française interdit la vente d'organes.


Big Data in Big Pharma = Big Bucks Minus Vital Data -- Why "minus"? This doesn't add up.

Hacking Pharma...

What do our genes have to do with quantitative biology, statistics & probability? Everything.

To cure many diseases in the future, we will have to target genes; NOT the organs. We have a LOT of cells and DNA (as opposed to the limited number of organs, of course).

MIT is currently offering a MOOC for you to learn quantitative or systems biology: 7QBWx. Week 6 is now live. On the menu: statistics in biology and genomics with R. Making disease predictions like you are in some casino (I'l go for Vegas), trying to evaluate what your chances are with, let's say, the roulette wheel spinning? Looks like fun!

Links to my previous posts about MIT-edX MOOC 7.QBWx here & here.
(On Twitter: #7QBWx)

Week 6:
"- Cool, huh?"
Thank you, Professor Paul Blainey!


From Broad Institute to Broadway?...

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The one thing you need to know about me: passionate about science and society, working on a writing project: genomic entertainment. From the Broad Institute to Broadway? I'm talking about the human genome project here -- so YES: I'm talking about YOUR own genome...

The Future of Cardiology

"Transplanting Gene into Injured Hearts Creates Biological Pacemakers"

"Here's What The Largest Genetic Analysis Of Schizophrenia Ever Just Revealed"
The message is: hope and humility.

Eric Lander, PhD: "The only way to succeed is to work together. Sharing the data, working across the silos... We can't do this alone!"

Exploring The Secret Connections Between Steve Jobs & "The Fault In Our Stars"

"Scientists Can Now Cut HIV Out of Human DNA"

The Story Of My Life

"IBM Aims to Make Medical Expertise a Commodity"