The Low-Coste Innovation Blog welcomes YOU

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". My name's Catherine Coste. I've earned myself two MIT digital diplomas: 7.00x and 7QBWx. Instructor: Eric Lander PhD.

My motto: Go Where You Are Celebrated, Not Where You Are Tolerated.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Appel à témoignage - Please share your experience - Teilen Sie Ihre Erfahrungen mit ! Don d'organes - Organ Donation - Organspende :

Appel à témoignage : lettre ouverte aux proches confrontés à la question du don d'organes (lire)

Please share your experience : letter to the attention of next-of-kin of donor-eligible individuals (read)

Im Krankenhaus oder in der Klinik wurden Sie nach dem mutmasslichen Willen Ihres Verwandten gefragt : ob er oder sie sich für Organspende ausgesprochen habe. Bitte teilen Sie Ihre Erfahrung mit ! (lesen)

Avertissement :

Merci de ne PAS poster de messages concernant la vente d'un organe et comportant des coordonnées téléphoniques, e-mail, etc. La loi française interdit la vente d'organes.


What Is Genomic Entertainment?

At the American Society of Human Genomics Congress 2014

From the Internet to the InnerNet:

Chromosomal walking; not schlepping, in Gangnam style -- with Eric Lander PhD, MIT & Broad Institute, one of the leaders of the Human Genome Project:

I love this video: genomic entertainment = linguistics + genomics; Noam Chomsky + Eric Lander. I've studied with both: Noam Chomsky at La Sorbonne & Paris X Nanterre, France (a long time ago) and Eric Lander, 2013-2014, MITx EdX genomics and quantitative biology workshop.

MIT in Gangnam style

American Society for Human Genetics Annual Meeting San Diego CA Oct. 18-22

Dena Talks DNA

The Future of Genomic Medicine - Anne Wojcicki, Richard Lifton and Eric Green:

L.O.L. (just for fun, right?)

Brief background of this blog

I started this blog, Ethics, Death & Health 2.0, in March 2005, in France, under French name "éthique et transplantation d'organes". Back then I was working with Intuitive Surgical Europe, Marketing. Having heard some persistant polemics among surgeons and other physicians about "brain death", I decided to start a blog to write about these polemics and see if people would respond. I intended to say just a few things actually but the blog went live (mainly on this topic, I'm afraid) until end of 2010, with testimonials coming from parents of deceased "donors" (these "donors" were young or elderly people), transplant surgeons, transplant patients, patients awaiting an organ, associations promoting organ donation, even people who were asked to donate vital organs from a dying loved one would seek counsel...

Did you know that French citizens are not allowed to have their genome sequenced? It is forbidden by law. Consent to "post-mortem" organ donation is written in the French law.

End of 2010 I met with Steve Jobs (surprise!!) who told me my blog was "stupid," as "people need hope". I was instructed to follow MITx MOOCs in genomics, as it was going to be "the future of medicine". I earned myself two edX-MITx certificates, 7.00x & 7.QBWx (no scientific background, PhD in German literature!). Ethics, Death & Health 2.0 is a blog about MOOCs in genomics, wet lab (biology) + dry lab (python, MATLAB) = quantitative biology; breaking news in genomics & "the creative destruction of medicine" and... genomic entertainment (I'm a writer).

I am very grateful for MITxBio MOOCs as they are fascinating, high quality and empowering for change in patient/citizen engagement and healthcare system.

Catherine Coste
@cathcoste on Twitter

Find the author of this blog on LinkedIn


Highly interested in precision "genomic" medicine, in mHealth and patient engagement. MOOC & book worm. Earned myself two MITx edX certificates: genomics and python (quantitative medicine).

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Send your questions & comments!

The one thing you need to know about me: passionate about science and society, working on a writing project: genomic entertainment. From the Broad Institute to Broadway? I'm talking about the human genome project here -- so YES: I'm talking about YOUR own genome...

I did a post-graduate teacher training at La Sorbonne university, Paris, taught German language and literature in middle and high school for over a decade and earned myself two MITx EdX digital diplomas (certificates) in genomics and quantitative biology: 7000x and 7.QBWx. Currently a MOOC student: "Explore Statistics With R" (edX). One last thing: I am a writer.

My message to Regina Holliday -- The Walking Gallery Of Patients (sent 08/18/2014):

My Motivation

Inspired by:

Welcome. My husband's the Grinning Cat, and my sister in law the Mad Hatter

Disneyland Paris, Oct. 2014

Special thanks to Florence, "La Boit'à Floh", for the cool hat! She's the one and only true Mad Hatter, I'm just pretending ...

Shouldn't giving people genetic literacy for free earn you a Nobel Prize?