The Low-Coste Innovation Blog welcomes YOU

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". My name's Catherine Coste. I've earned myself three MIT digital diplomas: 7.00x, 7.28x1 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

My motto: Go Where You Are Celebrated, Not Where You Are Tolerated.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Appel à témoignage - Please share your experience - Teilen Sie Ihre Erfahrungen mit ! Don d'organes - Organ Donation - Organspende :

Appel à témoignage : lettre ouverte aux proches confrontés à la question du don d'organes (lire)

Please share your experience : letter to the attention of next-of-kin of donor-eligible individuals (read)

Im Krankenhaus oder in der Klinik wurden Sie nach dem mutmasslichen Willen Ihres Verwandten gefragt : ob er oder sie sich für Organspende ausgesprochen habe. Bitte teilen Sie Ihre Erfahrung mit ! (lesen)

Avertissement :

Merci de ne PAS poster de messages concernant la vente d'un organe et comportant des coordonnées téléphoniques, e-mail, etc. La loi française interdit la vente d'organes.


What if the 3rd industrial revolution was about life?

DNA Reality Show

Contact Info

My jacket. I am now a proud member of The Walking Gallery of Health Care

Bioethics Chronicles in French
My translation into French of Atul Gawande MD's TED conf. (March 2012): "How do we heal medicine?" (Harvard)
Facebook Page: Homo Possessus (Fictional work)

Published Fiction: "Cliffhanger". Free PDF Version. Find this book on Amazon (French version, Kindle)

Brief background of this blog

I am a biology MOOC course evangelist. Medicine is changing due to discoveries in genomics that are happening right now. We all need to get the right information about that (hope; not hype).

I started this blog, Ethics, Death & Health 2.0, in March 2005, in France, under French name "éthique et transplantation d'organes". Back then I was working with Intuitive Surgical Europe, Marketing. Having heard some persistant polemics among surgeons and other physicians about "brain death", I decided to start a blog to write about these polemics and see if people would respond. I intended to say just a few things actually but the blog went live (mainly on this topic, I'm afraid) until end of 2010, with testimonials coming from parents of deceased "donors" (these "donors" were young or elderly people), transplant surgeons, transplant patients, patients awaiting an organ, associations promoting organ donation, even people who were asked to donate vital organs from a dying loved one would seek counsel...

Did you know that French citizens are not allowed to have their genome sequenced? It is forbidden by law. Consent to "post-mortem" organ donation is written in the French law.

End of 2010 I met with Steve Jobs (surprise!!) who told me my blog was "stupid," as "people need hope". I was instructed to follow MITx MOOCs in genomics, as it was going to be "the future of medicine". I earned myself three edX-MITx certificates, 7.00x, 7.28x1 & 7.QBWx (no scientific background, PhD in German literature!). Ethics, Death & Health 2.0 is a blog about MOOCs in genomics, wet lab (biology) + dry lab (python, MATLAB) = quantitative biology; breaking news in genomics & "the creative destruction of medicine" and... genomic entertainment (I'm a writer).

I am very grateful for MITxBio MOOCs as they are fascinating, high quality and empowering for change in patient/citizen engagement and healthcare system.

Catherine Coste
@cathcoste on Twitter


"Cracking The Code"
 Reading the book right now...

Genomic Entertainment?

Dying Steve Jobs: "Welcome to the digital Era of biology! Time to learn about it."

 Beauty & The Beast:

Link to video

My MOOC evangelist jacket. Cool! It was painted early 2015 by Regina Holliday, 
Founder of The Walking Gallery of Health Care & author of "The Writing on the Wall".

Our software (DNA) is making its own hardware (proteins, cells). Welcome to the digital era of biology! Time to learn about it.

Yes, this is dying Steve Jobs. Welcome to the digital era of biology!

Eric Lander (MIT, Broad Institute): "The Beauty of Knowledge"

La France raterait-elle le virage de la e-santé ?

My Kinky MOOCs

Thank you thank you thank you Regina Holliday, Founder of the Walking Gallery of Health Care! Just received my jacket... I'm in the middle of my final exam for 3rd diploma in genomics at MIT *right now*...

I am now a biology MOOC evangelist... 
So... How do you like my new jacket? ... Soon you will discover the story behind it...

Painted by Regina Holliday, Founder of the Walking Gallery of Health Care

Painted by Regina Holliday, Founder of the Walking Gallery of Health Care

Painted by Regina Holliday, Founder of the Walking Gallery of Health Care

My review of 7.28.1x on Coursetalk