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| MITx 7.00 MOOC "Intro to Biology - The Secret of Life". Lecture week 13.Instructor: Eric Lander PhD. |
"What has been so cool, in the past four or five years, as we talked about DNA sequencing, it's gotten so cheap that you could sequence every patient's own cancer and compare it to their normal DNA. And find that patient's mutations. And you can imagine a world where every patient will have their genome sequenced and their tumor sequenced. And a physician could use that information, as we collect more of it, to figure out which drugs to be using in which combinations. And that's a world we're all imagining right now, a world where that could happen. It's going to take a lot of work to get there. And in my opinion, it's going to take a lot of sharing.
Because we're going to need information pooled from patients around the world. Because we're going to have to learn which patients respond well to which drugs as a function of which mutations they have. And if they have a relapse and the cancer becomes resistant to the drug, which mutations have happened? We're going to need to pool all that, which means I think we're going to need to have some kind of common, agreed upon data sharing mechanisms where patients can voluntarily-- it's up to them-- but voluntarily say, 'count me in. I'm willing to share my data with other people sharing their data so we can build a big enough data set that we can learn what works best.' And I wouldn't be surprised over the next couple of years we see a kind of alliance across many institutions in the world and patients in many countries to try to create that knowledge base. It's kind of like a human cancer Genome Project, but where it's the humans who are involved who are doing it, or the patients who are doing it. And I think it's going to be a really important thing."
MITx 7.00 MOOC "Intro to Biology - The Secret of Life". Lecture week 13.
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