Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


"The Monster High Genome Project": Genomic musical hitting Growlway!

Genomic Entertainment: Ghouls Genome Project The Musical.


For Martin Wincker and Eric Topol MD: enjoy this nutty'n girly piece of fan art!
MonsterHigh Institute of Tech (MIT Salem), January 2014:


This morning, Operetta is rehearsing a song by Birdy: "People help the people", because she believes it to be the essence of what Internet-minded people call "2.0".
==> Operetta singing "People help the people": download audio file. 

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Why don't you run along and play with your chemistry set
http://www.flickriver.com/photos/nataloons/random/
"Things that are just patently absurd and impossible today turn out to be just hard a year or two from now, and turn out eventually to be a high school lab project a decade and a half from now or something like that. That's what modern biology is." Eric Lander PhD, one of the leaders of the Human Genome Project.

Genomic musical hitting Growlway?!? That's all very well (and madly ambitious), but how do you get all the way from the science of the human genome to some kind of genomic musical hitting... Growlway? Sounds like a nutty idea, doesn't it?

Well, I wanna try to tell you the whole story. I wanted to write something about our genes and about people helping the people, thanks to the Internet.

It all started with that writing assignment a friend of mine -- a Canadian writer and MD -- gave me last summer.

"Monster High", the Ughsome Musical! A writing (and singing) assignment:

==>  LINK

What happened next was... this: the ghouls thought their Mad Science teacher deserved a No-Bel Prize and they wanted to help him get it. How? Well thanks to their nutty secret project:

"The Monster High Genome Project" : Genomic musical hitting Growlway!

Special Halloween 2013! MIT Salem Students help their PhD Prof get No-Bel Prize with Genomic Musical in Growlway! 

==> LINK

But hey, wait a second! How do you get from Mad Science to some cool gene groove? I just don't get it... Well, here would be a good place to start:  

Working hard in biochemistry today... 

==> LINK

Our favorite ghouls just knew one thing: "What is in my body belongs to me. My genes belong to me. My body, my data."


"But mad science data does not translate into music, does it?," asked Operetta. She wasn't sure... How could you possibly listen to the music of your genes? 

"My Body My Data My Music": Gene Groove, The first Genomic Music App Ever!
 
==> LINK  

"Evolution is all about competition", says Clawdia, who new a thing or two about competition, as the teenager ghoul wanted nothing more than to set-up her own fashion empire. "I wanna be a smash, Marilyn wanted it, the cells in my body want it..." 

Marilyn & Marilyn and the "Evolution is about Competition" theory
 
==> LINK

That's all very well, but you know what? Mad science is made of 2% of talent plus 98% of hard work, where most people think that if you want to get a No-Bel Prize, you need 98% of talent and 2% of work (redefined as "serendipitous luck").

Oh, and just one last thing: if you want to learn how the MIT Salem ghoul students came to meet the One Direction boys band -- and then what happened?? -- I'm afraid you'll have to read... this:

The Ghoulfriends are having it their way!

==> LINK


"Well, choose me!"


https://www.facebook.com/catherine.coste

"Let me be your star" -- Bombshell/Smash, the Musical

=> Download audio file here.

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Or: you can download MP3 version of audio file here.

Lyrics



2 commentaires:

Ethics, Health and Death 2.0 a dit…

The Human Genome Project was the first time ever human genes got sequenced. The complete sequencing of the human genome was finalized some 10 years ago. It took more than ten years and cost a lot of money. Ever heard of the Monster High Genome Project at MonsterHigh Institute of Tech MIT Salem?

Ethics, Health and Death 2.0 a dit…

For more information, take a peek at this link: http://en.wikipedia.org/wiki/Human_Genome_Project