Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Assessing the risks of Synthetic Biology in Europe

A variation around Craig Venter's "My greatest fear is us not using the technology" in his book "Life At The Speed Of Light".

Catherine Coste, Blog: "Ethics, Health and Death 2.0", certificate in genomics (MIT). I'm a genomic geek with strong social media skills.

When some French modern renaissance woman with medium sized intelligence is trying to come to terms with traditional medicine and some "organ-specialist" surgeons in the era of digital biology and precision "genomic" medicine... Wanting to talk about the Hippocratic Oath, she is raving about some hypocritical oak instead... She also talks about "twinkering" with her own genome -- "everybody stands back, I'm doing sciences!"

Also, she speaks about some "23 or me" company. Did you know that in France, it is forbidden by law that any French citizen asks -- on his or her own initiative -- for his or her own genome to be sequenced? It is punished by prison and a fine (cf. recent French bioethics laws)... French citizens are cut from their own genome. Hence, California-based 23andMe company becomes "23orMe". Exception culturelle française.

The EU scientific committee is currently assessing the risks of Synthetic Biology. Interesting experience for both technical and non-technical reasons. People might have developed some perspective on the subject and public perceptions via their own experience. Have such questions ever gotten into that in any kind of depth? Particularly the public sentiments? This is the kind of stuff this talk show is dealing with...

"Assessing the risks of Synthetic Biology in Europe from Cath Coste on Vimeo.

Presence of the Illumina "super-duper sequencing machines" worldwide:

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