Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Post-mortem organ donation won't help you before you die, but the science of cryonics might

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A brain dead patient can "donate" his organs, but this prospect might not help him deal with his end-of-life issues (ever heard of "Ikigami"?)... When you are brain dead, you cannot consent to organ donation (informed consent and brain death don't agree). If you decide to donate your organs upon your death, you make this decision while you are alive and conscious. "In the unlikely event of ..." That's what the air hostesses say, right?
Dying in piece(s) or dying in peace?

This is the story of Kim. She suffered from glioblastoma, an incurable brain tumor. Glioblastoma is just another word for "Ikigami". She died at the age of 23, but before that, she had been looking for something that would help her die in peace at such a young age. She decided that this thing would be: freezing her brain.
This cryonic project was probably what helped Kim best before her death from brain cancer.

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