Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

A Musical About The CRISPR Revolution In Medicine?

Jesus CRISPR Superstar The Musical

Subject: revolution in medicine, coming from diverse fields: digital, bioengineering, biology, genetics, sharing economy.

From the disillusionment of doctors to the CRISPR panacea. Will CRISPR cure the terminally ill health care system? When biologists and engineers and computer scientists are trying to disrupt medicine…

Mocking the present health care system -- and IP, patents, DRM or digital locks, the Blockbuster Drug Quest of Big Pharma (cf. Chicago the musical)
Patients and people wanting to change things (cf Matilda the musical)
Multinationals (IBM of genomics -> Illumina) and open-access (engineers and people building platforms to cure multiple diseases, using CRISPR disease modeling. Ex: Mission Massimo, the Linux of Genomics?) and Google (23andMe -> the Google of DTC genetics) and Apple (the iPhone as your primary care physician, prescribing sensors & apps and interpreting them with algorithms).

Conventional medicine as a system where the Earth (Doctors) is placed at the center of the universe. Then comes a Doctor (pseudo: Copernicus), speaking about digital medicine, formulating a model of the universe that is placing the sun (Patients) rather than the Earth (Doctors) at the center of the universe. Disruptive! (cf. Memphis the Musical)

Writing the algorithm to cure health care system -> my body, my data.
Would you rather donate your vital organs, or your data? In organ-based medicine, it is vital that people agree to donate their organs (live organ donation, "post-mortem" organ donation). In cell-based medicine, it is vital that people consent to share their data (saving lives, just like organ donation).

Ownership of data by patient is crucial for digital medicine. In organ-based medicine, the question of ownership of medical data by patient is not relevant (patient is not a trained organ specialist). In cell-based medicine (the cell and its core, the DNA, RNA), the question of ownership of medical and genetic data by patient is becoming highly relevant.

My data on my digital device, smart because of the merge between IBM Watson and the digital device.
Empowering people: weapon of massive instruction -> MOOCs (My Kinky MOOCs, cf Kinky Boots)

Is Cell biology
Is molecular biology
Is genetics
Is a powerhouse
for microbes.

Computer science
Is medicine.

Python R Statistics MATLAB
Are tomorrow’s

Is making medical diagnostics.
Gene editing tool
Merry CRISPRmas
Is the new scalpel.

Left hand
Is for the wet lab
Right hand
Is for the dry lab.

Computer programmer
Is the new Doctor.

Is Medicine
Is Data is data is data.

Citizen science
Is Decentralized Medicine.
Dying Steve Jobs:
« Biology and I.T. have merged.
Time to learn about it. »

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