Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


"99 percent of people don't have an inkling on how fast this revolution is coming"




Aubrey de Grey: "Ending Aging" (book). Biogerontologist. "Free radicals may damage mitochondrial DNA causing potentially harmful mutations. Fix: insert backup copies of mitochondrial DNA into cell nucleus. Muations of the DNA in the cell nucleus contribute to cancer. Fix: delete the genes that let mutant cells divide forever,so that they die before killing us. Lysomal junk: waste builds up inside cells. as we age. Fix: use genes from soil microbes to break down those chemicals. Extracellular junk: waste builds up between cells. Fix: Stimulate the immune system to move the junk into the cell where it can be broken down. Sugar-protein molecular bonds: sugar & protein molecules bond, creating hardened layers of tissue. Fix: develop chemical compounds to break the unwanted bonds." --  "Fast 4ward", Chicago Museum of sciences and industry, Aubrey de Grey, "Ending Aging" (book), biogerontologist.

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