Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Andrea Ippolito: "MIT Hacking Medicine wants to develop a hack-in-a-box"

"MIT Hacking Medicine is much in demand as hospitals look for new ways to solve long-standing problems with a diverse group of brainstormers keen to share ideas. A few weeks ago it hosted a session at the BIO conference and even as I caught up with co-director Andrea Ippolito after her keynote at CONVERGE, she is gearing up for a business trip to India and has a long list of hackathons lined up this fall.
I’ll bet she wishes she could clone herself. Oddly enough, the organization is moving in that direction.
It is working on a website that would package its hacking medicine model to make it available to a wider audience. Although it typically works with hospitals, it has been approached by companies, institutions and organizations such as AARP, big pharma, medical device companies and surgical groups.
“I’ve gotten such a tremendous amount out of running medical hackathons, but we want this medical hackathon model to scale and to be sustainable,” said Ippolito.
This fall, the organization has an exciting schedule advancing its hacking medicine model. Its calendar includes a collaboration with the Clinton Foundation on a hackathon for women’s health. It will be limited to female participants who are engineers, entrepreneurs, clinicians and designers to promote STEM.
A critical care data hackathon at Beth Israel Deaconess will bring together data scientists and clinicians to analyze de-identified data on ICU patients pulled from electronic medical records by the hospital that could lead to new practice guidelines.
It has a second hackathon with Boston Children’s Hospital to develop innovative ideas in the pediatric space.  It’s also doing a Shark Tank challenge at Brigham Women’s Hospital that will look at ways to improve the in-patient experience as its theme.
Emergency department physicians are embracing the hackathon trend, too. MIT Hacking Medicine is doing a hackathon in Chicago with the American College of Emergency Physicians and Health 2.0.
Other projects it is eyeing include a medical hackathon for pain points in behavioral health and collaborations with surgeons."

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