Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Studying genomics & quantitative biology at MIT



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Professor Ernest Fraenkel, MIT: systems biology is the new tool that could help disrupt the cost escalation (exponential increase in the cost of drug development): welcome to the era of biology and big data.

7QBWx MIT and edX
Link to MOOC, June 2014
Why do we need systems biology?


"There's still a huge need to be able to measure other aspects of what's going on in the cell. And do very high throughput experiments, so we can cheaply and efficiently test not just one prediction from a model, but thousands of predictions, because one of the challenges of systems biology, is that if we're measuring thousands of things but we're only testing two, three, five, 10, then are we truly testing our models? And usually not, so we need better ways of doing the experimentation as well." Professor Ernest Fraenkel, MIT.





Week 4 (genomics): ex3: 100%; workshop 4: 100%.








1 commentaire:

Ethics, Health and Death 2.0 a dit…

Welcome to the era of quantitative biology: how systems biology will help disrupt the exponential increase in the cost of drug development. End of the 20th century: it costs about 1 billion to produce each new drug!