I'm the author of Airpocalypse, a medical thriller


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


I am an early adopter of scientific MOOCs. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs? Imagine all the people sharing their data...

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


All Thanks To DNA

For Emily Leproust, Twist Bioscience, San Francisco

Emily is... French artist Cabrel singing "Sarbacane" :-)
So i've been trying to write some lyrics (please don't laugh)

Emily's presentation: awesome!! Check it out here
Sarbacane, a song by French artist Cabrel

All Thanks To DNA (lyrics by Catherine Coste)

DNA is the next silicon 
Making from scratch 
DNA! valley of wonderment 
10 thousand genes 
Screen, select for desired function : 
Mammalian cells and algae bio- 
 factories, plants, construction… re- 
-genesis.

Designing DNA  
Mutations. Won’t you try 
Synthetic bio,
A billion dollar market, to change 
The world? Like making more food with less 
Arable land and fertilizers. 
Eliminate oil as a source 
Of our life 

Bacteria in soil feeds natural genes 
As a fertilizer to the plant and 
Gives vitamin A to children, thanks 
To gene clusters making rice with 
Vitamins. Vanilla from yeast, 
No phenol
Oh, no phenol 

With modified yeast you ferment sugar, 
Much healthier than vanilla coming from 
Oil. And use DNA to solve some 
Diseases. In yeast ferment and 
Sugar, make artemisinin 
You beat, oh 
Malaria. 

All thanks to DNA you can 
Modify white blood cells that will kill, 
Locate’n target, all of your 
Cancer cells, 
Oh cancer cells. 

Or making keratin-like proteins
Like the ones in rhino horn. Heroin 
Only is pricier than rhino horn! 
Squalene, a cosmetic coming 
From shark livers, can also be 
Engineered, 
And…
Spider silk 

Drug screening, antibody enginee-  
-ring, discovering new drugs, all thanks to 
DNA, that can help replace coal,  
Fuel, gaz, used to create plastic, 
Fertilizer, energy, not 
Sustainable 

Instead of oil, modify yeast 
And organisms like e-coli 
Create biofactories, use 
CO2, 
sunlight and 
sugar and 
DNA 

Oh, DNA 

-------------------------------------------------------------

Sarbacane
All Thanks To DNA


On croyait savoir tout sur l'amour 9
DNA is the next silicon 9
Depuis toujours, 4
Making from scratch 4
Nos corps par cœur et nos cœurs au chaud 9
DNA! valley of wonderment 9
Dans le velours, 4
10 thousand genes 4
Et puis te voilà  bout de femme, 8
Screen, select for desired function : 8
Comme soufflée d'une sarbacane. 9
Mammalian cells and algae bio- 9
Le ciel a même un autre éclat 8
factories, plants, construction… re- 8
Depuis toi. 3
-genesis. 4

Les hommes poursuivent ce temps 6
Designing DNA 6
Qui court depuis toujours, 6
Mutations. Won’t you try 6
Voilà que t’arrives 5
Synthetic bio,
Et que tout s'éclaire sur mon parcours, 9
A billion dollar market, to change 9
Pendue à mon cou comme une liane, 9
The world? Like making more food with less 9
Comme le roseau de la sarbacane. 9
Arable land and fertilizers. 9
Le ciel s'est ouvert par endroits 8
Eliminate oil as a source 8
Depuis toi. 3
Of our life 3

Pas besoin de phrases ni de longs discours, 10
Bacteria in soil feeds natural genes 10
Ça change tout dedans, ça change tout autour. 10
As a fertilizer to the plant and 10
Finis les matins paupières en panne, 9
Gives vitamin A  to children, thanks 9
Lourdes comme les bouteilles de butane, 8
To gene clusters making rice with 8
J'ai presque plus ma tête à moi, 8
Vitamins. Vanilla from yeast, 8
Depuis toi. 3
3 No phenol
oh, no phenol 4

Pas besoin de faire de trop longs discours, 10
With modified yeast you ferment sugar, 10
Ça change tout dedans, ça change tout autour, 10
Much healthier than vanilla coming from 10
Pourvu que jamais tu ne t'éloignes, 9
Oil. And use DNA to solve some 9
Plus loin qu'un jet de sarbacane, 8
Diseases. In yeast ferment and 8
J'ai presque plus ma tête à  moi, 8
Sugar, make artemisinin 8
Depuis toi. 3
You beat, oh 3
Malaria. 3

Alors te voilà  bout de femme, 8
All thanks to DNA you can 8
Comme soufflée d'une sarbacane. 9
Modify white blood cells that will kill, 9
Le ciel s'est ouvert par endroits, 8
Locate’n target all of your 8
Depuis toi. 3
Cancer cells. 3
Oh depuis toi 4
Oh cancer cells 4

Pas besoin de phrases ni de longs discours, 10
Or making keratin-like proteins10
Ça change tout dedans, ça change tout autour. 10
Like the ones in rhino horn. Heroin 10
Finis les matins paupières en panne, 9
Only is pricier than rhino horn! 9
Lourdes comme les bouteilles de butane, 8
Squalene, a cosmetic coming 8
J'ai presque plus ma tête à  moi, 8
From shark livers, can also be 8
Depuis toi. 3
Engineered, 3
And…
Spider silk 3

Pas besoin de faire de trop longs discours, 10
Drug screening, antibody enginee- 10
Ça change tout dedans, ça change tout autour, 10
-ring, discovering new drugs, all thanks to 10
Pourvu que jamais tu ne t'éloignes, 9
DNA, that can help replace coal, 9
Plus loin qu'un jet de sarbacane, 8
Fuel, gaz, used to create plastic, 8
J'ai presque plus ma tête à  moi, 8
Fertilizer, energy, not 8
Sustainable 4

Alors te voilà  bout de femme, 8
Instead of oil, modify yeast 8
Comme soufflée d'une sarbacane. 9
And organisms like e-coli 9
Le ciel s'est ouvert par endroits, 8
Create biofactories, use 8
CO2 3
sunlight and 3
sugar and 3
DNA 3

Oh, DNA 4

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