Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Gene Editing Tale

https://fr.pinterest.com/dalyapallot


Gene Editing Tale,

A black cat
Taking a stroll in a CRISP cold aiR
Sees a dog with such a white fur
It makes him purr.
The dog was running so fast

Stops cold,
Cat startled.

«  Where do you work? »
« - In barking-mad science »
« Me, in a China shop. »
There was silence
Between them. 
Both at a loss
Struggling to understand what stopped them.
Looking at the cobblestone
In vain
« It must be something in the air, then »
Said the dog. « - I wouldn’t know, » said the cat.
« I’m only dealing with porcelain
And price tags. And also, I work at night. »
« Touching anything without breaking it. »

The dog has had enough of white
The cat was tired of night shift.

« Because of the air,
I think we can help each other. »

« But how?? » The dog felt stupid for stopping and listening.
They both voiced their disliking
For each other. « - It ’s in our genes. »
Experimenting that CRISP thing in the aiR on our genes
Will change medicine. 
Let’s spare the lab rats. The cat felt the passion
In the dog’s eyes.
The dog’s mind was racing.
In the CRISP aiR
They began to fear
Both may be turned into one cow,
Bacteria science getting trickier.

I want Star Trek science, not mad science,
Ironized the cat. There was silence.
The dog started regretting the whole thing,
Afraid of becoming a fat cow he stopped eating.

« Because of the air,
I think we can help each other. »

« Did you just say something? »
«  - Me? No, » answered the cat.
Now the air was talking.
«  I’m confused. Air is not a country, it has no language. Air just
shuts up. «  - In a China shop, air is a polyglot, »
Said the cat. He seemed to know about
CRISP aiR more than the dog,
A mad-science rock star.

« We have to work together.
Not because of you, not because of me.
Because of the air. »

They listened, as the air started
Talking in Spanish and Python.
« Is the air coding genes
To edit our proteins? »
« - Meh », shrugged the cat.
Dog voicing regret,
But it was too late.
The air could also speak AI.
Radiologists got edited out
Of medicine. Cat became art,
A mona lisa with the cat’s tongue.
Dog was edited into Spock.

« Because of the air,
I think we can help each other. »

Rhyming genes.
« I feel stupid for liking you »
Said Spock the dog to
Hungry Mona Lisa. 

« Changing medicine
Must be like painting genes.
It's been centuries,
But nobody can explain Mona Lisa's smiles. »

Patient is Data
Doctor is Software.
Define data:
3 billion DNA base pairs
20 tera octet; 20,000 gigas
20,000 billion information per patient,
We each have 2 million mutations
Faced with the reference genome;
But far fewer diseases;
25 million mutations per cancer cell.
The analysis of all this requires Principal component analysis (PCA)
With up to 800 million factors
Doctor House himself
Could not analyze 20 tera bytes of data per patient
Within 15 minutes, which should include
Patient unclothing and dressing again.

Mona’s smile is an Algorithm 
Cat and dog both here to serve Him.

« Because of the air,
I think we can help each other. »

A.I. and CRISP aiR,
Getting along like cat and dog,

1 commentaire:

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