Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


a "Love Song for Heart Rhythm Specialists"

Lyrics: (VERSE:) "Hello there, baby, are you new in these parts?

I am a doctor, yeah, a doctor of hearts!
You sure are pretty, baby, that I can see
And you’d look better yet beside an MD

I’m think our chemistry is hot and it’s real
But holy moly, that’s not all that I feel
I sense constriction in my vascular flow
So here is what I wanna know:

CHORUS:
Is it your eyes?
Or atrial fibrillation?
Is it love I need?
Or Neurohumoral Modulation?

Do you make my heart race?
Or have I got tachycardia?
When I look at your face
I nearly get bradycardia.

I get a rippin’ arhythmia
And palpitations, too...
I guess I mean my heart skips a beat
When I look at you!


That may sound technical, but baby, my god
You have a powerful effect on my bod
I’ve been in practice for a whole lotta years
I’ve never heard this kind of ring in my ears
No ER doc will have a clue what to do
My diagnosis is, the affliction is you
This kind of heart attack is rare as can be
You’d better do a workup of me!

Is it your smile?
That screws with my physiology?
Do I need your kiss?
Or a lotta pharmacology?

You got my heart in your hands
And got my mind in the gutter
You do a thing to my glands
And give me atrial flutter

I get a rippin’ arhythmia
And palpitations, too...
I guess I mean my heart skips a beat
When I look at you!

I get a rippin’ arhythmia
And palpitations, too...
I guess I mean my heart skips a beat
When I look at you!"

--David Pogue

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