Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Job Interview

"Would you like to work in medical education entertainment?"

" - No thanks. I've seen the gulag (been there, done that) and I am not talented enough to make it look and sound and feel and smell like Disneyland. Happy to know that some other people are, though."

"Would you like to be an activist?"

"- No thanks, what's left of my mental health (not much, really) would vanish in the process, like the Titanic into the ocean. Plus, I can think of some people who really, really wouldn't like me to become an activist. Gotta care about the people you care about, right? Plus, I don't enjoy receiving death threats so much. I'd rather forget I ever did, actually."

"What did you study?"

" - Genomics. Still working on it, and I don't think I'll ever give it up. Just earned myself another MIT certificate (molecular biology, advanced level), so I'm super happy!! And also, literature (I'm a post-graduate in German literature, language and civilization). Love it, too. Can't say I have a passion for the microbiome, but I am fascinated (like many others) by cool genome editing tools like CRISPR-Cas9 and population genomics and bioinformatics. I'd like to write about it. Help speed things up, yes."

"Would you like to work in genomic entertainment?"

" - Definitely. Would love that!! I'm just a writer."

"Who are your favorite scientists and why?"

Nina Tandon is Katy Perry
Robert Darnell at the NY Genome Center is Louis Pasteur

J. Craig Venter is Michael Jackson
Eric T'Pol MD, sorry, I meant to say Topol, is Mr. Spock

 "How do others see you?"

" - Errrr..... (Where's Charlie??)"


"Who are the most important people for your work as a writer?"

" - My co-writer Isabelle, my husband, the teenagers around me. I never miss an update on T'Pol's twitter account ... Sorry, I meant to say, Eric Topol MD. Also, I spend a lot of time reading articles by MIT Tech Review."

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