Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Avaler un microprocesseur comme un médicament

JM Billaut (BNP Paribas) : "Bientôt vous allez avaler un microprocesseur comme médicament... si, si ... Mais un "chip" ou une puce électronique, pour fonctionner, allez-vous me dire, a besoin d'électricité ... Qui fait la batterie ? Vous ... Ah ma p'ôv dame quelle époque !" (03/08/2012)

A mon avis, il va falloir accompagner l'innovation et contribuer à changer les perceptions ... Comment l'industrie pharmaceutique s'adapte t'elle à l'émergence des "biotechs" (alliance de l'électronique et du médicament) ? ...

"The era of digital medicine just got one step closer to reality. The U.S. Food and Drug Administration (FDA) has for the first time approved a digestible device — a sand-particle sized microchip that can be embedded in drugs to monitor patients’ response to treatment, according to a new report in Nature.
The device is currently only approved for use with placebos but Proteus Digital Health, which is developing the technology, hopes approval with other drugs will be forthcoming in the near future. Co-founder and chief medical officer for Proteus George Savage tells Nature the enhanced pills could be used to treat everything from drug-resistant tuberculosis to diabetes.
'The point is not for doctors to castigate people, but to understand how people are responding to treatments,' Savage tells Nature. 'This way doctors can prescribe a different dose or a different medicine if they learn that it’s not being taken appropriately.'

So how does this digital pill work? The sensor itself is made of a tiny silicon chip containing trace amounts of magnesium and copper. When a patient swallows it, the pill generates slight voltage which responds to digestive juices. The voltage sends a signal to a patch worn by the patient, which transmits relevant information to a healthcare provider’s mobile device.
If that sounds like something out of a science fiction movie, get ready for a whole new world of healthcare. Nature reports similar technologies in the works include implantable devices that wirelessly inject drugs at pre-specified times and sensors that would deliver a patient’s electrocardiogram to their smartphone."

http://mashable.com/2012/08/02/fda-digestible-device/



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