Precision Medicine will need to get out of the pharma silo that is based on symptoms
Welcome to the digital era of biology (and to this modest blog I started in early 2005).
To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!
Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.
After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.
Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).
I love Genomics. Would you rather donate your data, or... your vital organs?
Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.
Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).
Injectable Oxygen Keeps Alive Without Breathing
The invention has been developed in Boston Children's Hospital, by John Kheir, MD...
"Scientists have made a breakthrough that could save patient's lives and open up the possibilities for underwater exploration.
Dr. John Kheir first began looking at ways to oxygenate the blood without breathing due to a tragic experience with one of his patients, a young girl. She was suffering from pneumonia and at one point her lungs started to fill with blood. It took 25 minutes to remove the blood from her lungs, but unfortunately it wasn’t enough time to prevent a cardiac arrest, leaving the girl in a serious condition which eventually lead to her death.
Potential uses for the new technology include medical, military and private. Military uses could include covert teams being able to stay submerged for 30 minutes at a time without having to come up for air. Private sector could include rescue teams being better protected, or an oil rig crew being able to fix underwater damage without the need for scuba equipment."
Injectable Oxygen Could Help People Breath Underwater; Keep Patients Alive After Lung Failure
"Chemical engineers, particle scientists, and doctors created injectable oxygen particles that carry three to four times the oxygen in our blood cells.
The emergency, IV oxygen-delivering syringe contains microparticles of oxygen gas and liquid. Details of the microparticles were published in a June 2012 issue of Science Translational Medicine.
Led by Dr. John Kheir of the Cardiac Intensive Care Unit at Boston, chemical engineers, particle scientists, and medical doctors teamed up to create the tiny particles for patients having difficulty breathing.
One of Dr. Kheir's patients was a 9-month-old girl who had pneumonia and trouble breathing. Five minutes after checking up on her, Dr. Kheir and his team were alarmed by the bell and returned to her room, where they found her face covered in blood. Her lungs began filling up with blood and doctors spent almost 30 minutes pumping it out.
It was too late, the girl went into cardiac arrest and her brain was deprived of oxygen. She died three days later.
Dr. Kheir was a fellow at the time of the incident and recalled wanting to create oxygen that would effectively support patients intravenously.
Thus arose the injectable particle. It could sustain patients between 15 and 30 minutes after experiencing respiratory failure.
'This is a short-term oxygen substitute — a way to safely inject oxygen gas to support patients during a critical few minutes,' Dr. Kheir talked about the technology in a press release. 'Eventually, this could be stored in syringes on every code cart in a hospital, ambulance, or transport helicopter to help stabilize patients who are having difficulty breathing.'
The particle has three to four times the oxygen of the red blood cells circulating in our body, and is encased in a cell membrane that consists of fat that's flexible and easily flows through the capillaries.
But the particle didn't just develop overnight. Researchers took years to whittle it down to the right oxygen concentration and size required to make it safe to inject. They used a sonicator that uses sound waves to blend the oxygen and fats together.
'Some of the most convincing experiments were the early ones,' Dr. Kheir said. 'We drew each other's blood, mixed it in a test tube with the microparticles, and watched blue blood turn immediately red, right before our eyes.'
Experts are saying the potential uses for this new particle could extend to military, covert teams, even oil rig crews who would be able to breathe underwater for 30 minutes at a time without coming above for air."