La thérapie génique fournit une alternative non invasive à l'invasive biopsie sur patients transplantés rénaux.
"Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts":
Background"The standard test for the diagnosis of acute rejection in kidney transplants is the renal biopsy. Noninvasive tests would be preferable."
Methods"We prospectively collected 4300 urine specimens from 485 kidney-graft recipients from day 3 through month 12 after transplantation. Messenger RNA (mRNA) levels were measured in urinary cells and correlated with allograft-rejection status with the use of logistic regression."
Conclusions"A molecular signature of CD3ε mRNA, IP-10 mRNA, and 18S rRNA levels in urinary cells appears to be diagnostic and prognostic of acute cellular rejection in kidney allografts. (Funded by the National Institutes of Health and others.)"