Scientific MOOCs follower. Author of Airpocalypse, a techno-medical thriller (Out Summer 2017)

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

I am an early adopter of scientific MOOCs. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs? Imagine all the people sharing their data...

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Monster High The Ughsome Musical

[Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.]

In 3013, at Monster High School. Laurel and Hardy, Stan and Oliver in blood and flesh, teach Mad science and Skultimate Roller Maze.

Spectra Wondergeist just brought back an unexpected guest star: Audrey Hepburn. Yes, Audrey from New NY is back to (high)school and Spectra is saying as usual: "I've been waiting my entire death to cover a story like this!"

A monster scoop for her online blog Ghostly Gossip for sure... Will Audrey perform in Operetta's ultimate scary-sweet musical?

Meowlody wants the lead role in this musical and is ready to do whatever it takes to get it...

Now let's see who YOU might be... You are a Monster High Music Society member for sure. A veeeery dead-icated one... "Matilda" The Musical deals with Physical Education at school. The new musical will be all about physical deaducation ;-) This time Clawdeen Wolf will wear her latest hot platform heels. You adore monsters like...

... Draculaura who are in love with love, and Rochelle Goyle, the dead-fully protective. The truth is she's travelled beyond the stone she sits on (and the grave she lies within). Goyle's a fantastic song writer (her family has been protecting the Monster High Library like, forever).

Your best friend is Purrsephone, whose fave subject is mad science, especially the module on genetics.

You have three avatars to represent you - choose among the latest Monster High Fearbook and/or make up new student body profiles!

Of course you can be one of those avatars...You can (and must!) write, sing, dance, be a fashionista, look for your ancestors, and let us know everything about your dreams and genes!
From left to right: Purrsephone, Clawdeen Wolf and Meowlody
This morning, Purrsephone and Meowlody are rehearsing the musical. They've hardly gotten started, but there's already a bat flying in the ointment... Purrsephone's just had a big massive row with her "normie" boyfriend. She says that if she doesn't get to feel what eternal love is SOON, she's just gonna live. Meowlody has just found The scary-cool fiancé she hopes Purr will want to die for (remember she wants the female lead role in the musical). Igor is Abbey Bominable's brother. Actually, Abbey and Igor are twins. But I told you there was a bat flying in the ointment: Abbey and Purrsephone both claim they've just discovered each other's freaky flaw, at the moment both are avoiding contact and want to send each other back in her iCoffin. "OK, no fang-outs at the moment, then. We'll just sing..." says Meowlody who's all about work (and she can be such a clawsome singer).

Here's Meowlody singing for Purrsephone-and-Igor, while our already famous trio of friends Cleo de Nile, Frankie Stein and Draculaura are watching (and listening). Igor is watching too - watching Clawdeen, who has just made a grand entrance. She thinks the's the most creeperific singer of all times. "I thought you were into fashion, NOT into singing!", says Purrsephone when Clawdeen asks for a role in the musical. "Hey sista, don't put your paw down when I ask for your help!"

"Someone like you" (Adele): download audio file.

Meanwhile, Operetta is getting ready for the (not so much) secret party her ghoul friends are throwing for her sweet sixteen... She hasn't heard about the musical YET...

This is just one monstrous memory of the musical, out of many...

I'm afraid YOU'll have to keep a wicked record of all the comings and ghoulings at the best monster school in town... I'd say you'd better stay pretty much dead-on... 

Ready?... Go!
Last minute... 

My name's Rochelle Goyle, I'm living and studying in the city of Scaris, France. Plenty of Gargoyles here. I'm writing some songs for the upcoming musical. My Ghoulfriends say I'm shy and emotional and to tell you the truth I keep to myself a lot...
 Here's my fave song:

For Julie-Anna and her ghoulfriend Rochelle Goyle ;-)

==> "Bim Bam Boum" audio file.

Operetta says John Diedrich singing "The Phantom of the Opera", "Music of the Night", is to die for... "Well, this is the very reason why you died... This way the world gets to hear you and your eternal song...", says Cleo de Nile. "Look, that singer is quite old now..." She looks tired today... A tired Cleo never says nice things... "Yeah, looots of memories... Quarrel and conflict with that bloody history teacher again... You see... History - been there, seen that! I'm 5.842 years old... Oh my Ra! My internal monologue is mostly annoyed sighs". 

Seems like nothing can take Cleo's blues away today...  

Meowlody is rehearsing "Cats, Memory, The Musical" as a vocal warm-up exercise. She wants to comfort Cleo with that song today, but Cleo's mood lies burried deep deep away from Ra's shunshine...

"Cleo will eat a mummy wrap for lunch today, I guess..."  

Operetta and Rochelle are giggling and winking at each other: "Meet you at Kings Kross for one of our favorite fang-outs! But nobody shall cross a queen... As the captain of the Fearleading squad, as Head Fearleader, Cleo de Nile wants her team (and herself) to be part of that new musical. Some student body outta have informed her about this project, right from the beginning. "BUT THIS IS THE BEGINNING!", says Purrsephone. When she's being pushed over the edge, she looks a little bit like this Lazzarus statue...

Cleo's only answer: she storms out of the room, yet pauses, staying behind the door as she hears Meowlody singing "Meowmory"...

download audio file here

Then she scoffs... "I'll know better..."

In the afternoon, Cleo is back with Spectra Vondergeist, the journalist. Spectra is very much into what she calls "oldie but goodie": and with that she means her special role play book:  

"Vampire: The Masquerade".

"Any progress with the musical?", asks Cleo, pouring herself some tea and helping herself to the cookies she's just brought for the girls. Everybody's grateful for the bloody cookies (Cleo always bakes her own cookies at home, her secret recipe includes two drops and a half of salamander blood, 'cause she says it helps regenerate your neurones). Everybody's tired and hungry. "this isn't going anywhere really", sighs Dracu Laura. Basically each girl wants the lead female role for herself and wants to prove her own singing and acting and dancing (she turns to Clawdeen) is rising above the pack... What we need here is teamwork, instead of that each of us keeps competing against the others... 

Cleo chuckles a bit when she hears that. "Now look... Grab a cookie and come check this out... This book was brought for us by Spectra. She thinks this is just what we need..."

"A role play book?" Operetta sounds interested. "This is a brilliant idea. I used one when writing the musical 'The Phantom of the Opera'. But of course, that was a long time ago..."
"Why an older version of this book?", asks Rochelle. "I can get you the vintage edition, for their 20th birthday. My parents told me it is available at the Ghoul High School..." "Yeah that'd be creeperific", says Cleo. Operetta points out that she needs to write the music to a new Monster Mashional anthem for the Fearleading Mashionals this year. Why not include it in the upcoming musical? "Clawsome", says Meowlody. She's very much into Operetta's music, as she often causes a mass freak out when people get to hear her new songs... 

"But we need a story, for this musical...", says Abbey Bominable. 

"I suggest we write about a mad scientist, who is going to win the No Bells Prize for mad science." 

"Wao, Abbey does have a soft spot for Jackson Jekyll", says Frankie Stein. 

"Two math freaks and geeks think alike ;-)", winks Ghoulia. 

"And we need to come up with something waterish too, for Lagoona Blue". Abbey gives a nod of appoval. 

"See, girls, you're getting organized, finally", says Cleo (she loves to sort people out).

"Operetta, can you sing a little something for us?", asks Abbey. "I want something that makes you shiver... It's definitely too hot in here... I need to cool off or I'm just gonna live..."

"Ever heard 'The Music Of The Night' being sung by a woman?" asks Operetta. 

"No, of course not. This is a Man Man Man's world, I mean, song..."

"Well, you tell me. Does this sound like a man?" asks Operetta. She starts singing "The Music Of The Night"...  

Download audio file here.

This is precisely the moment Audrey Hepburn makes her entrance. Everybody stares in amazement.

Audrey Hepburn, the killer star (hence a ghoul star too...) !!!!!! 

"Hi girls, sorry to interrupt, but I'm looking for a journalist you might know: Spectra Vondergeist. I'm scheduled to meet her at 5:00 PM this afternoon..."

"Yes, Madam, I'm here!", says Spectra. "It's a pleasure to welcome you at Monster High School", says Spectra with a smile that's shining brighter than I ever could tell...

Spectra has been very much into genomic entertainment lately... Did you know that your genes can sound like music? You can interprete your genes and make them sound like music, or, even better, a song! When Clawdeen hears that Audrey is here because of a partnership project for their next musical - a genomusical that will hit Growlway!! - with Audrey and her favorite ughsome fashion designer Hubert de Genevenchy, she puts on a catwalk show to make flesh crawl and fur stand on end... The spotlights in the room may have replicated the effect of a full moon, once again...

"The first genomusical ever, hitting Growlway!! It will be OUR musical!" 

Spectra introduces Clawdeen to Audrey. "Clawdeen wants to set up her own Fashion Genome Empire... Howlywood, Scaris, Growlway, Los Ghouless, and she says that's just to start with! She wants to work with Asia and Africa... She says fashion is in our genes... Well, she's just shown you that..." (the girls start giggling...) "She says in the future, we'll be able to regenerate our clothes just like we regenerate our skin... and that a very good metabolism will be able to engineer a beautiful dress, splendid colors, great design - matching your personality! You'll see the dress on your skin and you'll just want to die for it... Next thing you know, you'll be dancing and singing!"

Spectra: "Our Clawdeen is a fierce fashionista..."

"Her theory is very interesting, I've been working on this myself for quite some time, now", says Hubert de Genevenchy. "I'm looking forward to be working with you, Clawdeen! We'll be cementing our elite mark in the fashion world. A musical is an excellent place to start. By the way, did you know how we say 'brand' in French?"
Rochelle Goyle answers: "Une griffe", literally meaning: "a claw". "That's correct!" Hubert smiles at Rochelle. "What a gorgeous gargoyle..."
"You're such a timeless beauty, Audrey!" says Rochelle - and she certainly knows about timeless, as she is 415 years old... 

Monster High Doll Little Dead Riding Wolf / Draculaura/ Rotwölfchen
Singing "I never met a wolf who didn't love to howl" (Bombshell/Smash The Musical) in karaoke style.

==> Download audio file here.

"Purrpurrella is my middle name", says Purrsephone... I'll claw my way out for all of us to go to Growlway! Purrpurrella is a creature from the future... I plan on spending a lot of time in the future. If I don't, I think I'll just live! Seriously, girls! I've been waiting my entire death to live in the future!!"

Robecca Steam says: "The more geeky and girly scientists would love to find out about their Style Genome here: I love steampunk style at the moment! Geeky ghouls are smoking hot!"
"Oh and these are my ughsome steampunk boots..."
Operetta and Abbey are working together on a song project: "Science is the only news."
Steward Brand: "Science is the only news."

"Science is the only news.

When you scan through a newspaper or magazine, all the human interest stuff is the same old he-said-she-said, the politics and economics the same sorry cyclic dramas, the fashions a pathetic illusion of newness,
and even the technology is predictable if you know the science.
Human nature doesn't change much; science does, and the change accrues, altering the world irreversibly.
We now live in a world in which the rate of change is the biggest change.
Science has thus become a big story."
"Bolts! This ain't no Mad Science, I swear!"   
"DIY Bio: Gene Transplant. After organ transplant comes... gene transplant", explains Frankie Stein.

Frankie's fab lab:
Genomic Entertainment Hitting Broadway!

Ever wondered how "The Music Of My Genes" might sound like?

"Well here's a hint. Watch this..."

Watch me

"Then... hear this!" You'll see that...

Gene Groove is in your DNA!

So Cleo de Nile, the Captain of the fearleading squad, could sing, after all! "See," she says, "history of sciences, been there, seen that! We were asked to donate our blood, then our organs in case we die. Now believe me, gene therapy is the next thing. We'll be able to transplant genes into cells, which means we'll be able to rewrite our DNA! Some diseases are just written in our DNA, our genes, and no matter what we do, we can't recover from them, we can't avoid them. But if we correct this DNA problem, then we can get a healthy DNA instead of the faulty one..."

"Then we'll be able to live for hundreds and hundreds of years, just like you've always wanted, Cleo!", says Frankie.

Frankie is 15 days old; Cleo is 5,842 years old... "This is the reason why we should get to sing 'The Music Of Our Genes' in our musical!" says Cleo. 

"Not a bad idea," says Clawdeen. "But who's heard about genes? And about the fact that we might be able to read our genes like we can read a book? The Book of Life... Hardly anybody, I guess..." "This is the reason why we are going to sing about our genes in our new musical. How can we make sure people know about their genes? What do you think?" asks Cleo. "Singing 'The Music Of My Genes' sure is a good place to start!", says Frankie. She'd been around for only 15 days, but don't forget her fave subject is history. "I wanna make history!", says Frankie. Audrey Hepburn couldn't help but smile. "Just follow your heart, girls! This is what I did with my movie 'Breakfast at Tiffany's', this is how I became a star..." Clawdeen smiles back: "I'm already a clawsome star..." "Yes, I think we've all noticed that," answers Audrey and everybody laughs.

Venus McFlytrap had her genes analysed and found out about some of her ancestors coming from China... Now she wants to learn a bit of Mandarin Chinese... Catherine, her Chinese language teacher, would like her to sing a beautiful and famous Chinese song: "The Moon Represents My Heart"

Catty Noir has a real temper. She wants to color her life. She wants to become a musical artist. "Catty is a very superstitious person, which is a fact she is aware of herself and readily admits. Much of this is expressed through ritualistic behavior. She always has a piece of a broken mirror with her on stage, always enters the stage left and after having walked under the stage ladder first, always leaves the stage right and then walks under the stage ladder there, and her pre-concert meal also is always the same: thirteen items, of which seven chicken nuggets, five apple slices, and one strawberry shake. is a black werecat with long, pink hair and pink eyes. In her own words, she loves 'big, flashy, larger than unlife outfits because they are ghoulishly glitzy, creeporifically cool and fangsolutely fun!'"

==> Catty singing "Colored Woman" (Memphis, The Musical): audio file.



"Some got chances, some got choices, Some got freedom in these states. Colored women got few chances, Got few choices on our plates. Mama told me there are limits For dark-skinned girls stuck in this light-skinned world. Once in a while I lose myself in dreams- A silly girl full of silly schemes. Now along comes a man whose skin is white and pale, A shiny fool full of shiny tales. He says he'll make the people hear me. He'll force this world to fin'ly see me. Is he a lie like ev'ry other man Or Lord could he somehow/ could he somehow/ Could he somehow help to free me? Mama told me not to dream big, But Mama lived her life running scared. I am stronger and I'll fight longer! I'll do what Mama never even dared! Colored woman with few chances, Has to do what she must do! I will make my colored dreams come true! For this is one colored woman who will color Her life her way!"

16 commentaires:

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I love dead-icated teams!!

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Fearleaders enrol now! Send your application to Cleo de Nile, Head Fearleader...

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Get ready for a creeperific musical!...

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"Do you believe in love at first fright? Or should I walk by again...?" asks Heath.

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Flo and Yo just wrote: "You're a mouse werewolf". Good one!
Why a mouse? 'Cause I'm seriously into cheese (well I'm French)...
Why a werewolf? Sometimes my moooooood is all over the place and believe me, this ain't no pretty sight... Plus when it happens, nobody's safe (even Purrrsephone in person gets goosebumps)...

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Flo et Yo : "T'es une souris garoute!"

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@Flo and Yo: The mouse is in the cheese...

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Pix taken yesterday with my iPhone in Rye, UK.

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Rochelle (drawing):

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Bim Bam Boum: Mozart L'opéra rock.

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Portable Genomics a dit…

the more geeky and girly scientists would love to find out about their Style Genome here:

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@ Portable Genomics: Thx, I'll have my creeperific team look into this asap. Robecca Steam and Abbey to start with, and of course Jackson Jekyll...

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Venus (pic):

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Catty Noir:
Catty Noir doll:

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Rochelle Goyle: