Super-organs: building body parts better than nature http://t.co/DbIMgMfZAZ
— Jean Michel Billaut (@Billaut) August 24, 2013
"FANCY a liver that works a little harder? Synthetic DNA circuits inserted into human stem cells could soon allow us to build new organs with unprecedented precision and speed. The circuits can be designed on a computer and assembled from ready-made parts ordered online. The technique could prove an efficient way of making organs for transplant without the worry of rejection, and raises the tantalising possibility that it might one day be possible to upgrade the organs we were born with. Human cells have already been used to create a tiny liver and a set of neurons.
'At the moment, the aim is to normalise cells, but in future, enhancement has to be on the menu,' says Chris Mason, a professor of regenerative medicine at University College London, who wasn't involved in the work.
Control from inside
"'You assemble it into one large logic circuit and put it into the cell,' Guye says. 'It's interfacing with the natural system. We're not replacing anything, we're putting a control layer on top.'
Oxford Journal Nucleic Acids Research - Rapid, modular and reliable construction of complex mammalian gene circuits
ABSTRACT Rapid, modular and reliable construction of complex mammalian gene circuits
We developed a framework for quick and reliable construction of complex gene circuits for genetically engineering mammalian cells. Our hierarchical framework is based on a novel nucleotide addressing system for defining the position of each part in an overall circuit. With this framework, we demonstrate construction of synthetic gene circuits of up to 64 kb in size comprising 11 transcription units and 33 basic parts. We show robust gene expression control of multiple transcription units by small molecule inducers in human cells with transient transfection and stable chromosomal integration of these circuits. This framework enables development of complex gene circuits for engineering mammalian cells with unprecedented speed, reliability and scalability and should have broad applicability in a variety of areas including mammalian cell fermentation, cell fate reprogramming and cell-based assays.
Organs enhanced with sensor or that release drugs on demand
In theory, he says, we can imagine creating a human organ for detecting magnetic fields – birds have such things, for example. But augmenting organs, rather than making entirely new ones, is within closer reach. Synthetic biology provides a rapidly increasing number of biological sensors that react to different stimuli. These could be inserted into tissues so that gene expression could be controlled by light alone, say, which may allow less invasive treatments.
People with brain disorders like Parkinson's, caused by the loss of nerve cells that produce dopamine, could benefit from neurons that release an extra hit. Growing 1000 more-potent brain cells instead of 100,000 normal cells would make cell therapies more affordable and quick to implement, says Chris Mason of University College London.
Other ideas suggested by researchers contacted by New Scientist include organs that can release drugs on demand, that are resistant to parasites or that break down toxins we can't deal with."
"Super-organs: building body parts better than nature", 24 July 2013 by Douglas Heaven, Magazine issue 2927.
"Super-organs: building body parts better than nature. "