Precision Medicine will need to get out of the pharma silo that is based on symptoms
Welcome to the digital era of biology (and to this modest blog I started in early 2005).
To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!
Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.
After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.
Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).
I love Genomics. Would you rather donate your data, or... your vital organs?
Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.
Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).
The Stuntman, the Nurse and the Little Girl: "The Fall", a stunning movie
The patient is a stuntman (with a broken leg and a broken heart), the nurse (or some vicious ambitious young actress) a gold digger, physicians turn out to be either a surrealist version of Darwin or some false-hearted lead actor in Hollywood...
Life, death, resurrection, everything happens in a hospital, or... in the fall of a stuntman in Hollywood.
A stunning movie, to say the least...
"Los Angeles,1915: stuntman Roy Walker (Lee Pace) is hospitalized, as he is bedridden and possibly paralyzed after a jump he took in his first film. He meets Alexandria (Catinca Untaru), a young Romanian-born patient in the hospital who is recovering from a broken arm, and begins to tell her a story about her namesake. Alexandria is told she has to leave, but Roy promises to tell her an epic tale if she returns the next day. The next morning, as Roy spins his tale of fantasy, Alexandria's imagination brings his characters to life. Roy's tale is about five heroes: a silent Indian warrior (Jeetu Verma), a muscular ex-slave named Otta Benga (Marcus Wesley), an Italian explosives expert called Luigi (Robin Smith), a surreal version of Darwin (Leo Bill) with a pet monkey, and a masked swashbuckling bandit. An evil ruler named Governor Odious (Daniel Caltagirone) has committed an offense against each of the five, who all seek revenge.
The heroes are later joined by a sixth hero, a mystic. Alexandria vividly imagines her friends and people around her appearing as the characters in Roy's story. Although Roy develops affection for Alexandria, he also has an ulterior motive: by gaining her trust, he tricks her into stealing morphine from the hospital pharmacy so that he can attempt suicide; a choice driven by his love leaving him for the actor for whom he provided the stunt footage. However, Alexandria returns with only three pills, having mistaken the "E" on the piece of paper Roy gave her for a "3". The stories become a collaborative tale to which Alexandria also contributes. Alexandria herself becomes a character: while Roy is the masked bandit, she is his daughter. Roy talks Alexandria into stealing a bottle of morphine tablets locked in a fellow patient's cabinet, and then downs it all. The next morning, Roy awakens from his sleep and realizes he is only alive because his neighboring patient is receiving a placebo rather than actual morphine. Alexandria, desperate to help Roy, sneaks out of bed to the pharmacy. She climbs onto the cabinet but loses her footing, falls, and is badly injured. She receives surgery, after which she is visited by the bewheeled Roy, where he confesses his deception. He encourages Alexandria to ask someone else to end the story, but she insists on hearing Roy's ending. Roy reluctantly begins the rest of the story. The heroes die one by one, and it seems that Governor Odious will be triumphant. Alexandria becomes upset, and Roy insists, "It's my story." She declares that it is hers too and exerts some influence on the course of the tale. Finally, the epic tale comes to an end with only the Bandit and his daughter remaining alive and Governor Odious dying. Roy and Alexandria, along with the patients and staff of the hospital, watch a viewing of the finished 'flicker' that Roy appeared in. With everyone laughing, only Roy's smile is broken in confusion when he sees that his life-threatening jump has been edited out of the film as another stuntman jumps instead. Alexandria’s arm heals and she returns to the orange orchard where her family works. Her voice-over reveals that Roy had recovered and was now back at work again. As she talks, a montage of cuts from several of silent films' greatest and most dangerous stunts plays; she imagines all the stuntmen to be Roy." (http://en.wikipedia.org)