Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

"I know when the singularity will occur"
"(...) [l]et's just admit this: The race to win the Singularity is over, and Google has won.

They have the world's greatest computational capacity, the most expertise in massively distributed processing, the greatest collection of minds interested in and capable of work on AI, the largest store of online data, the largest store of personal data, and the largest library of scanned, computer-readable books. That includes textbooks. Like, all of them.

All they have to do is subscribe to Springer-Verlag's online journals, and they'll have the entire collected knowledge of humanity in computer-readable format.

They almost certainly have the biggest research budget for natural language processing with which to interpret all those things.

They have two of the four smartest executives in Silicon Valley.

Their corporate strategy for the past 15 years can be approximated as 'Win the Singularity.'

If someone gave you a billion dollars today to begin your attempt, you'd still be 15 years and about two-hundred and ninety-nine billion dollars behind Google. If you believe in a circa-2030 Singularity, there isn't enough time left for anybody to catch up with them.

(And I'm okay with that, considering that the other contenders include Microsoft and the NSA. But it alarms me that Google hasn't gone into bioinformatics or neuroscience. Apparently their plans don't include humans.)"

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