Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Working hard in biochemistry today...

Working hard in biochemistry today... Thanks to my 2 favorite study buddies for their support!

Lagoona Blue, Mattel ("Monster High")
Lagoona: "Within 48 hours, I can give you a protein that binds any DNA you want! Did you know that just a few years ago, biochemists have discovered a protein that can wrap itself along the DNA helix!  all the way long, an alpha helical protein. Now, this protein has just the right shape to sit itself into the groove of the DNA and wrap itself around... It's an identical repeating unit around and around... except for one little difference. Two amino acids can differ in each of those subunits. Here, all subunits are identical except for two amino acids. And those two amino acids point into the DNA. And they recognize which base of the DNA it is!!"

Source: Eric Lander PhD, "Intro to Biology", "The Secret of Life", MOOC MITx, 7.00x

So now it's time for some cool... Gene Groove!

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