Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


My Tribute To Paternalistic Medicine

In this old song by French singer Michel Sardou, it is said that what is left of Verdun (World War I) or of (The Great) Terror is an old man walking by. Paternalistic medicine can be compared to Verdun or to The Great Terror...

"Finalement, Verdun, ce n'est qu'un vieux qui passe."
De Verdun à la médecine paternaliste, certains vous diront qu'il n'y a qu'un pas ...

Et comme le dit la chanson, Verdun, c'est un vieillard usé ...



An old man walking by...

French pioneer of heart transplant in Europe Christian Cabrol. Pic: http://www.theatre-huchette.com/actualite/evenements
Today's pioneers can be seen at MIT (US), or at the Max Planck Institute (Germany), and as my MIT prof Eric Lander keeps saying: "Don't forget that the fastest computers today are in China, not in the USA."


Emmanuelle Charpentier
Feng Zhang & colleague


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