Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

"Water is a highly, highly structured business"

Lagoona Blue as a student of MITx MOOC 7.00 "The Secret of Life" Eric Lander PhD
This morning, Lagoona Blue was studying Hydrogen Bonds (not Hydrogen Bombs!!), a peaceful thing actually. She has learned that Oxygen is greedier than Hydrogen, on hence there'll be some negative charge on the side of Oxygen and some positive charge on the side of Hydrogen (water molecule H2O). The positive charge and the negative one behave like a magnet: they attract (+/- or -/+) or they repel (+/+ or -/-). "In a big cup of water, all of those molecules are doing that to each other. They're all weakly interacting by those little magnets. Hydrogen bonds mean: the water is all coupled to each other by these weak forces. It turns out that, nonetheless, because there are so many of them, water is highly, highly structured. There's a tremendous amount of structure in water. This is so strong bugs can walk on water. Bugs are walking on hydrogen bonds. The net that the bugs are walking on, that surface, is provided by the strength of all those hydrogen bonds. No hydrogen bonds, the bugs sink.

Next time you think about water, think about water as a highly, highly structured business..."

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