Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Clawsome Genomic Musical Hitting Growlway!

Special Halloween: MIT Salem Ss help their PhD Prof get No-Bel Prize w/ Genomic Musical in Growlway! 

Monster High Ghouls - Abbey Bominable (Amazon)

MonsterHigh Institute of Tech (MIT Salem), 31st October 2013: 

Abbey and her friends Operetta and Lagoona have been sitting at their computer, studying the human genome for their Mad Science assignment for what seems like forever... 

The ughsome ghouls, MIT Salem students, are still dreaming about their genomic musical and about Growlway... they are more determined than ever to become stars in Ghoul-York... 

Operetta's iCoffin is out of synch, and she's been missing quite a few invites at the theatre for the past few weeks, as Lagoona and Abbey want her to focus on the current task at hand: understand the human genome and write ughsome-clawsome songs that her fangtastic voice would deploy in the air like endlessly reproducing chromosomes on double helices whirling and twisting around each other, and then opening wide and making replication bubbles and forks... People are gazing at these helices, hypnotised, as they get to see and hear the rhythmic twirls of their genes, with Operetta performing on stage...

"Operetta, you aren't daydreaming again, are you? I suggest you get busy..." 

"- Abbey, you abominable dreamkiller..." says Operetta, while Lagoona, humming to herself, is doing some online research for the problem set at hand...

"Teamwork... let me giggle", says Lagoona... She's reading aloud what she found on the internet: "Even now, decades after the discovery of double helix by Crick and Watson, people are still studying why genes are turned on, what particular times, what's the machinery that does it. A lot of it has to do with proteins that will bind at those sites of DNA. Why are they binding at those sites? Because they got made. Why? Because the genes that were responsible for those proteins got turned on. But how did they get turned on? Well, because other things turned them on... It's turtles all the way down!" 

MOOC MIT 7.00x "The Secret of Life", "Intro to Biology", Eric Lander PhD.

"Our Mad Science teacher is really ughsome... He should write this musical with us...", says Lagoona.

"- Yeah, we'll get to talk to him about this project, but before we do, we have a bit of homework to do, don't we, ghouls?", asks Abbey.

"We outta talk to him about Ghoul-York, Growlway and fame, don't you think? He's gonna love it", says Operetta.

"Girls, I wanna bet he's more interested in getting the No-Bel Prize, says Lagoona, still tweeting and looking up stuff on the internet...

Ghoulia Yelps and Cleo de Nile, Amazon
Operetta: "I'm gonna sing to him about glamorous Ghoul-York, then. Wait, not sing. Howl. Like I'm a werewolf. Like I'm Clawdia... I can do that... Wanna hear?"

"OK, ghoul, give it a shot, and then, back to work... I'm learning so much I just think my poor brain's gonna live...", says Lagoona.

Operetta is singing "Empire State of Mind - NY" by Alicia Keys. Ghoulia Yelps and Cleo de Nile are just back from a Mad Science course. They wanted to check on the three ghoul friends, see if they are making any progress in their work...

Operetta singing "Empire State of Mind - NY" by Alicia Keys.

==> Download audio file here.  

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

"Ah at last, she's stopped howling... You should leave this to Clawdia, really...," sighed Cleo.
"Oh my Ra, this extraordinary relief I am feeling now is a gift. You might call this the Operetta effet, I guess..."Abbey broke in cuttingly, adressing to Cleo: "ô your Royal Highness, did you get to speak to our Mad Science teacher?"

"I did...", said Cleo...
"Sooo?" asked Lagoona.

"You ghouls were right. He might be waiting for the No-bel Prize."
"You ghouls were right. He might be waiting for the No-Bel Prize... He's told us about what he's already accomplished in the course of his decades-long career at the Monster Institute of Technology here in Salem: helping decode the human genome!! And we all know what a huge project this was, this Human Genome Project... Unprecedented, unparallelled in human history, and Ra knows I've been there and seen it all..."

Ghoulia: "In my opinion, this should win him the No-Bel Prize... But he also said he's started a MOOC, a massively open online course, Intro to Biology, to bring genomics and molecular biology and biochemistry home to people worldwide..."

"Wao that's massively ambitious!," said Lagoona.
"-So is No-Bel Prize," replied Cleo.

"My weakness was certainly brought home to me by the heavy work I'd been assigned to do, when I got registered for this Mad Science course...," sighed Abbey.

"Speaking of homework, are you ghouls ready with yours, because as No-Bel Prize worthy his life's work might be, our dear Mad Science teacher has got some fresh-new experiments for us try out -- as homework... For all of us... This includes you, Operetta."

"Operetta is day dreaming again... Sooo, judging by that, I'd say she's gonna sing again... pretty soon... Oh my Ra!" 

"- How about now? Keeping your eye on a Prize...Well it's quite something... I wonder how it feels... probably like... being a star, or wanting something sooooo bad: 'I wanna be a star, the Marilyn of Mad Sciences!,' can you imagine?"

"Speaking of Mad Science... sorry, Lagoona, but your last homework assignment got you... a C. No doubt you'll do better next time!,"says Ghoulia with a big comforting smile.

"Which means hard work again, still clawing my way to some science diploma, doesn't sound very marilynish, there's nothing glamorous to this stupid C", says Lagoona."Abbey, I'm gonna need your claws and brain again..."

"Glad if I can be of some help, Lagoona... Let's see..."

Lagoona, Abbey Bominable and Operetta are exploring various materials for their Genomic-Musical-hitting-Growlway!! What will this be about? The Human Genome Project, of course!
"No, let's hear," interrupts Operetta. "You will now get to hear what it feels like to keep your eye on a Prize, or on a lead role in a musical, for that matter...."

"But the No-Bel Prize has nothing to do with a female lead role in some stupid musical!", says Lagoona. 

"We're talking about 'Genomic Entertainment' hitting Growlway, not about some average, made-in-Mediocrity musical..." 

"Oh my Ra you're all obsessed..."

"What if Genomic Entertainment were yet another major achievement, I mean, something really really big, helping him get his No-Bel Prize -- just like that MOOC 'Intro to Biology'?," asks Lagoona.

"Waiting and waiting, putting in hard work day after day after day after day... Sounds like I'm gonna live... Well, Marilyn for one certainly knew how this felt like... Lemme sing it to you," said Operetta.

"They keep moving the line"
"Smash, Bombshell", the Musical: "They Keep Moving the Line"

==> Operetta is singing: "They Keep Moving the Line"

This link is an audio file. Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

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