Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Repo! The Genetic Opera



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Low-Coste Innovation Blog a dit…

Amazon: Likening Repo! The Genetic Opera to its predecessors, Little Shop of Horrors and Rocky Horror Picture Show, conveys this film’s high camp and operatic bursts of song, but does little to describe how absolutely bizarre Repo! is. Like Rocky Horror, Repo! was written for stage performance by Darren Smith and Terrance Zdunich, who stars as a Graverobber, dolled up in vampiric makeup to resemble Rocky Horror’s iconic tranny, Dr. Frank-N-Furter. Hiring newbie director, Darren Lynn Bousman, fresh out of film school to shoot this mutant movie, Smith and Zdunich clearly focused on writing comedy into extremely gruesome slasher scenes, which works with mixed results. Stills of comic strips contextualize each scene, telling the story of biotech corporation Geneco’s repossessions of organs that they implanted into various patients to save human lives during a long history of operations. Organs, here, were bought on credit, and as the economy nosedives, citizens of this a makeshift Gotham City cannot pay bills, and must forfeit their lives to repo men make a killing around town, literally. Heading this enterprise is CEO Rotti Largo (Paul Sorvino), who has two bickering sons, Luigi (Bill Moseley) and Pavi (Nivek Ogre), whose white facemask is third generation Phantom, borrowing directly from Winslow Leach’s in Brian De Palma’s Phantom of the Paradise. Central to the plot is head repo guy/slaughterer, Nathan Wallace (Anthony Head of Buffy the Vampire Slayer), who hides his career path to preserve his sexy teenage daughter, Shilo’s (Alexa Vega), innocence. As Shilo discovers her godmom, Blind Mag (Sarah Brightman), and the "Z"-addicted surgery slut, Amber Sweet (Paris Hilton), she embarks on adventures through an urban landscape constructed of metal gear, corpse piles, and S/M zombie girls, while dad straps people up in his torture chamber to take back body parts. Hmmmm. Since Repo! looks likes a Marilyn Manson video, its musical niche sensibility will only appeal to fans who like Goth and Industrial music. To anyone who doesn’t go for that look, it does impress for its sheer dedication to choreography and song. In the least, Repo! The Genetic Opera is an anomalous glimpse into visionary horror. --Trinie Dalton