Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


What "logistical challenges" are being posed by death row inmates willing to give their organs?

"A condemned child killer will not be allowed to donate organs to his ailing mother and sister before or during his execution this week, Ohio prisons officials said Tuesday after determining the process would pose significant security and logistical challenges.

The request from Ronald Phillips to donate a kidney and his heart came Monday, less than 72 hours before he is scheduled to die by lethal injection.

Phillips has said through his attorneys that the request was not a delay tactic, but rather an attempt to make a final gesture for good.

Prison officials scrambled to review Phillips’ last-minute request, which they called unprecedented, but ultimately could not figure out a way to get the 40-year-old to and from an offsite hospital while following security procedures leading up to an execution. Phillips is scheduled to die Thursday by an injection of a sedative and painkiller that has never been used in a U.S. execution.

The department says it will be up to his family whether the organs are donated after his death. It is unclear whether they would be viable when Phillips’ body is turned over to his family." (Source: http://chronicle.northcoastnow.com/2013/11/12/ohio-death-row-inmate-denied-wish-to-donate-organs/)


On the "logistical challenges":

"It is unclear whether they [Phillips' vital organs] would be viable when Phillips’ body is turned over to his family." Well, they won't. Ask the Chinese army. They know how to execute people so that they will get (and sell) fresh organs for transplant...

Truth being: transplant surgeons ain't like magicians. They need to retrieve living organs for transplant - from a "dead" body. Ahem. Yes, it's a bit gory and creepy and maybe a tiny bit transgressive...

Solution to this problem: death row inmate has been cleared to give a non vital organ before the execution of his death sentence: a kidney. Then he'll be brought back to prison where he will be executed in July. Chinese army shoot prisonners in the head so they can be brain dead (but organs still living) and sell the organs for transplant. 10,000 transplants in China each year (guess how: executions, plus poor people selling a kidney...)

We read everyday in the press that this is about to change... Seriously? 

This will change... when artificial organs will be available for transplant... Can't wait for 3D bioprinting... and preventive medicine thanks to genomics, the science of the human genome...

11 Disturbing Cakes That Look Like Body Parts

Read the full text here: http://mentalfloss.com/article/12748/11-disturbing-cakes-look-body-parts#ixzz2khYSAHVp
--brought to you by mental_floss!

 

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