Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Brain Death: when a counter-intuitive definition of death, dating back to the 70s, makes specialists and families clash over it

http://edition.cnn.com/2013/12/28/health/life-support-ethics/index.html
This is just one from many situations where you get to understand that so called "post-mortem" organ donation is a veeeeeeery complicated question. Donating your organs after your death? This would be an absolute no-brainer (no pun intended). But it gets much trickier than that: you donate your vital organs UPON your death. No wonder some people came up with a much simpler definition for "next-of-kin organ donation decision". They call it "sacrifice"...

We just started digitizing the brain... This will probably not make the "brain-death" question/polemic any easier. Digitizing the brain might turn out to be some very good way to disrupt brain death, which "scientific" definition dates back to the 70s and ever since never stopped causing both specialists and families to clash over it. Some MDs just don't believe in "brain death", while some others do. But wait a minute: since when do you have to believe in some scientific stuff? Aren't you supposed to prove it instead? So many ways to die, but... I thought death was kind of unique.

Or did they clone it back to the 70s? I can't wait for 3D bioprinted organs... and, I dunno... Maybe digitizing the brain will add some real scientific stuff to that "brain-death" death thing?...

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