Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Cystic Fibrosis Gene Therapy


https://www.facebook.com/catherine.coste
"In-silico experiment of the human CFTR sequence to identify common disease causing mutation and development of small drug therapies for cystic fibrosis." (LINK)

07/2012; In proceeding of: International Conference on Intelligent Systems for Molecular Biology, Volume: 20 
ABSTRACT "Cystic fibrosis, an autosomal recessive genetic disease is associated with the mutation in the human CFTR protein sequence. So understanding of the CFTR Protein’s structure and component’s is important for the development of small drug therapies for cystic fibrosis. To start the experiment, the amino acid sequence of CFTR was obtained from the database and thus analyzed using some available software. The major regions, domains and motifs of the protein were identified. Mutations were evaluated which can potentially cause cystic fibrosis. Based on the analysis we can understand the protein components of the CFTR protein which is important for the development of the small drug therapies. We have presented the structural components of the CFTR protein which is our subject of interest. Then as we know it has a large number of mutations in the gene thus it allows us to evaluate the individual mutations which are responsible for cystic fibrosis. To address specific research question, we identified three disease causing mutations in this gene that are known to be associated with CF. Till now the conventional way of treating cystic fibrosis is by the use of physiotherapy, antibiotics and pancreatic supplements. We can also suggest gene therapy for the CF. We do this by identifying the mutation responsible for the disease and then transferring a normal copy of the CTR gene into the lung of the cystic fibrosis patients. This can be effectively done by using viruses and liposomes. With the development of better new viruses and liposomes these problems can be solved."

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