Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


After the Human Genome Project (mapping the human genome) comes the Human Connectome Project (mapping every neuronal connection in a brain)

"The question is not whether we can upload our brains onto a computer, but what will become of us when we do." The death of brain death?... "Only a few months ago, the British physicist Stephen Hawking speculated that a computer-simulated afterlife might become technologically feasible."
Mapping the human genome - Mapping the human brain

"In some ways, the scientific problem of understanding the human brain is similar to the problem of human genetics. If you want to understand the human genome properly, an engineer might start with the basic building blocks of DNA and construct an animal, one base pair at a time, until she has created something human-like. But given the massive complexity of the human genome — more than 3 billion base pairs — that approach would be prohibitively difficult at the present time. Another approach would be to read the genome that we already have in real people. It is a lot easier to copy something complicated than to re-engineer it from scratch. The human genome project of the 1990s accomplished that, and even though nobody really understands it very well, at least we have a lot of copies of it on file to study.

The same strategy might be useful on the human brain. Instead of trying to wire up an artificial brain from first principles, or training a neural network over some absurdly long period until it becomes human-like, why not copy the wiring already present in a real brain? In 2005, two scientists, Olaf Sporns, professor of brain sciences at Indiana University, and Patric Hagmann, neuroscientist at the University of Lausanne, independently coined the term ‘connectome’ to refer to a map or wiring diagram of every neuronal connection in a brain. By analogy to the human genome, which contains all the information necessary to grow a human being, the human connectome in theory contains all the information necessary to wire up a functioning human brain. If the basic premise of neural network modelling is correct, then the essence of a human mind is contained in its pattern of connectivity. Your connectome, simulated in a computer, would recreate your conscious mind."

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