Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


"DNA Structure, the Race"

http://boingboing.net/2012/11/08/the-turn-of-the-screw-james-w.html
"And so began the race to understand DNA structure. It involved a 25-year-old ornithologist from Indiana and a 35-year-old rather talkative physicist, a Brit, who had worked for the admiralty during World War II.
The ornithologist--erstwhile ornithologist in college-- one James D. Watson, and the physicist, working in the admiralty during World War II, Francis Crick.
And Watson came over on a fellowship to the Medical Research Council labs in Cambridge, England, and was there to work on structures of things with Francis Crick, who knew a lot of crystallography, knew mathematics and crystallography.
And they were incredibly well known around the Medical Research Council because they talked a lot and did very little. They did a lot of talking. And they had big ideas about what they were going to do, including this DNA thing. They knew this was really important.

They weren't supposed to be working on DNA.

They were supposed to be working on something else. The distinguished head of the lab, Sir Lawrence Bragg, didn't want them working on DNA because King's College down in London was supposed to be doing the DNA stuff. But you know how kids are. They really wanted work on this DNA stuff. And they made some models. And they were kind of crazy models. And some of them were kind of embarrassing models in 1952 that they were making that anybody could have seen they had it wrong and so on. They began going down to King's College and talking to Rosalind Franklin, who was working on crystallizing and doing X-ray diffraction patterns on DNA, invited there by Maurice Wilkins.

The two of them didn't get along.

Rosalind didn't really have anybody to talk to about her stuff, and there was a bit of tension between them due to a bunch of misunderstandings. Crick and Watson came down and made a pain of themselves.
And they talked back and forth. And Rosalind Franklin hated all this abstract models stuff. She wanted hard data. Crick and Watson loved models. And you had this tension back and forth there.

Rosalind Franklin, at one point, was sure, based on her data from one form of DNA, that DNA was certainly not a helix, she even published a death announcement, a black-rimmed paper saying the death of the helix, saying that it certainly wasn't going to be a helix.

And it was back and forth.
And it was sort of comic.

At the beginning, in 1952, it had a feeling of Keystone Cops to it in a way.

And you've got to read Jim Watson's autobiography The Double Helix because he tells these stories." 

7.00x Intro to Biology- The Secret of Life, Eric Lander PhD.

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