Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Screwed up scientists, really? A Crick and Watson behind-the-scene story


The sugar-phosphate backbone is on the outside and the four different bases are on the inside of the DNA molecule.
Kind of fascinated by that Crick and Watson story, as MIT PhD Eric Lander tells it in his MOOC lectures... I'm talking about MIT 7.00x MOOC "Intro to Biology: The Secret of Life".

Actually those two guys, Crick and Watson, were outsiders, regarded by their academic collegues as total idlers. They were thought of as unreliable kids, screwed up scientists, good enough for talking at any great length and making ridiculous models and achieving nothing but this one thing in particular: annoying and annoying further serious scientists working hard on their serious experiments... Academic insiders are the real thing, you see... Not those idle kids who will take nothing seriously... Except that Crick and Watson got famous for their achievements in genomics... They've discovered the molecular structure of DNA (the double helix), which got them a Nobel Prize.

http://petapixel.com/2013/10/29/honored-photograph/
"Doesn’t look like much, does it? But, depending upon your definition, this photograph, a team effort by 9 men, is the most honored picture in U. S."

This photograph has been taken by 9 "screwed up pilots" whose story reminds me of Crick and Watson's... A misfit crew, made of nine perfect army rebuttal examples, each in its own style, and their DIY plane went on the deadliest mission ever (without proper authorization, by the way, just like Crick and Watson working on the double helix of human DNA), in South Pacific in the early days of World War II...

The Most Honored Photograph

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