Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Edit the genome in all different ways and make cuts and changes in a quick way, with CRSPRs

Meet with one of those babies from
the CRSPR family...
"The ability to do this in mammalian cells is about 12 months old. It's only just been developed. And everybody I know is off using CRSPRs to go edit the genome in all different ways and make cuts and make changes, because it's incredibly quick. They're still working out all the details, how perfectly it has to match. A new paper just came out the other week about that. One I just saw was being submitted on the details of how to perfectly design CRSPRs and things like that. (...) People can now write their whole circuitry in DNA."" Eric Lander PhD, MIT Professor in Genomics.

From the "Genomics-it's-happening-right-under-our-feet" Department:

CRSPR (pronounce "crisper") means clustered regular short palindromatic repeats. And this is a Bacteria-Side Story...


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