Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

"Catastrophic care"

“Rarely has the irrationality of the system been so convincingly demonstrated.” 

"I greatly appreciate the kind words. But I think he’s missed my point. My argument in Catastrophic Care is in fact that the health care system is very rational. Health care is an industry, and as such, it has responded almost perfectly to the misguided economic incentives wrapped up in private insurance, Medicare, and Medicaid.
Our health care debate is imprisoned by a set of assumptions that have gone unexamined for at least fifty years. Most care, we are told, is used by only a small percentage of patients. Care is so expensive that only insurance could make it affordable to anyone who isn’t rich. Care is too complex, too nontransparent, and too urgent to rely on consumers to serve their normal role. Care is nondiscretionary, so consumers can never have leverage. As the population ages, the cost of care must rise. And most tellingly, technology is driving up the cost of care. In every other industry, technology drives down costs and consumers are considered perfectly capable of making decisions for themselves. But health care experts always argue that their field involves so many unique complexities and irrationalities that it requires massive central assistance and control (usually involving their guidance). My book doesn’t ignore these old chestnuts; it argues they are simply wrong and that their impact on health care policy has been disastrous."

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