Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


On the fundamental concern of privacy in the digital era: "The Circle" by Dave Eggers


"The Circle" by Dave Eggers
“A parable about the perils of life in a digital age in which our personal data is increasingly collected, sifted and monetized, an age of surveillance and Big Data, in which privacy is obsolete, and Maoist collectivism is the order of the day. Using his fluent prose and instinctive storytelling gifts, Mr. Eggers does a nimble, and sometimes very funny, job of sending up technophiles’ naïveté, self-interest and misguided idealism. As the artist and computer scientist Jaron Lanier has done in several groundbreaking nonfiction books, Mr. Eggers reminds us how digital utopianism can lead to the datafication of our daily lives, how a belief in the wisdom of the crowd can lead to mob rule, how the embrace of ‘the hive mind’ can lead to a diminution of the individual. The adventures of Mr. Eggers’s heroine, Mae Holland, an ambitious new hire at the company, provide an object lesson in the dangers of drinking the Silicon Valley Kool-Aid and becoming a full-time digital ninja . . . Never less than entertaining . . . Eggers is such an engaging, tactile writer that the reader happily follows him wherever he’s going . . . A fun and inventive read.”
—Michiko Kakutani, The New York Times (Source: Amazon).

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