Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Doomsdare, a medical thriller (action taking place in Beijing) Fall 2016; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2017). Special thanks to Prof. Emmanuel Lincot, lawyer David Kilgour and Isabelle Provost for their help.

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

Stethoscope is out. Stethophone is in. But MDs want to be the guardians of procedures.

The stethophone is being used in Brazil, in China and India, but not in Europe or in the US, where doctors want to be the guardians of procedures. Symbol of that: lab coat and stethoscope... And as a result: a health care system that is in a crisis: absurdly expensive and underperforming.
"Topol is also a big believer in the power of genetic sequencing. If people find out what’s in their DNA, he said, they can work to prevent future illness – someone with a predisposition toward melanoma can stay out of the sun, for example. But Topol may be in a small minority. According to the American Medical Association, he said, '95 percent of doctors don’t feel comfortable with genomic data.'"

This video shows why the US health care system is in a crisis: spending billion dollars on the 125 million ultrasound procedures that are performed in the US each year is just an example. Patients could use this device -- the stethophone -- instead, to perform their own echocardiogram and ultrasound. This would save  the healthcare system a hundred billion dollars... Now this stethophone is being used in Brazil, in China and India, where it's something big, but not in Europe or in the US, where doctors want to be the guardians of procedures, and hence ignore it. Symbol of that: lab coat and stethoscope... I bet you have not even heard of that stethophone in the first place, right?

==> Watch video here:

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