I'm the author of Airpocalypse, a medical thriller

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

I am an early adopter of scientific MOOCs. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs? Imagine all the people sharing their data...

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).

UW engineers invent programming language to build synthetic DNA

"Similar to using Python or Java to write code for a computer, chemists soon could be able to use a structured set of instructions to 'program' how DNA molecules interact in a test tube or cell.
A team led by the University of Washington has developed a programming language for chemistry that it hopes will streamline efforts to design a network that can guide the behavior of chemical-reaction mixtures in the same way that embedded electronic controllers guide cars, robots and other devices. In medicine, such networks could serve as “smart” drug deliverers or disease detectors at the cellular level."

An artist's rendering showing programmable chemistry.
Yan Liang, L2XY2.com
An artist’s rendering shows DNA structures and a chemical reaction 'program' on the screen. A 'chemical computer' executes the molecular program.

 "The findings were published online this week (Sept. 29) in Nature Nanotechnology.

Chemists and educators teach and use chemical reaction networks, a century-old language of equations that describes how mixtures of chemicals behave. The UW engineers take this language a step further and use it to write programs that direct the movement of tailor-made molecules.
'We start from an abstract, mathematical description of a chemical system, and then use DNA to build the molecules that realize the desired dynamics,' said corresponding author Georg Seelig, a UW assistant professor of electrical engineering and of computer science and engineering. 'The vision is that eventually, you can use this technology to build general-purpose tools.'
Currently, when a biologist or chemist makes a certain type of molecular network, the engineering process is complex, cumbersome and hard to repurpose for building other systems. The UW engineers wanted to create a framework that gives scientists more flexibility. Seelig likens this new approach to programming languages that tell a computer what to do.
'I think this is appealing because it allows you to solve more than one problem,' Seelig said. 'If you want a computer to do something else, you just reprogram it. This project is very similar in that we can tell chemistry what to do.'"

An example chemical program.
"Yan Liang, L2XY2.com
An example of a chemical program. Here, A, B and C are different chemical species."

"Humans and other organisms already have complex networks of nano-sized molecules that help to regulate cells and keep the body in check. Scientists now are finding ways to design synthetic systems that behave like biological ones with the hope that synthetic molecules could support the body’s natural functions. To that end, a system is needed to create synthetic DNA molecules that vary according to their specific functions."

"The new approach isn’t ready to be applied in the medical field, but future uses could include using this framework to make molecules that self-assemble within cells and serve as 'smart' sensors. These could be embedded in a cell, then programmed to detect abnormalities and respond as needed, perhaps by delivering drugs directly to those cells.
Seelig and colleague Eric Klavins, a UW associate professor of electrical engineering, recently received $2 million from the National Science Foundation as part of a national initiative to boost research in molecular programming. The new language will be used to support that larger initiative, Seelig said.
Co-authors of the paper are Yuan-Jyue Chen, a UW doctoral student in electrical engineering; David Soloveichik of the University of California, San Francisco; Niranjan Srinivas at the California Institute of Technology; and Neil Dalchau, Andrew Phillips and Luca Cardelli of Microsoft Research.
The research was funded by the National Science Foundation, the Burroughs Wellcome Fund and the National Centers for Systems Biology."


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