Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


"Bucket list of an idiot"

"Brave or crazy? Dom Harvey proves that he's both by letting his friends and family set him a bucket list of mad tasks.

Hello, my name is Dominic Harvey and I am an idiot.

Ever since the movie The Bucket List came out in 2008, people have been creating their own lists of things to do before they kick the bucket. Some of the things on these lists look so difficult that I wonder if dying would be a better option than actually ticking off the items. The purpose of these lists seems to be to make the list maker feel like they are doing something more with their life than sitting around writing lists and watching Morgan Freeman DVDs.

I am a paid-up life-member of a place called the comfort zone. People always go on about the importance of getting out of your comfort zone. Not me. Any day I can stay inside it is a good day. All of which makes it a bit odd that I decided to complete a bucket list of my own. Not just any bucket list though. This is a reverse bucket list - a bunch of stuff that I could have happily passed away without ever doing - stuff like getting a tattoo I’d instantly regret, arm wrestling an All Black and being the model for a life drawing class - and I recruited some of my closest family and friends to compile it for me. In hindsight, this was a bad idea. But here it is - my pain, discomfort and humiliation for your pleasure - The Bucket List of an Idiot." (Amazon)

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