Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

3D printing starts saving lives.

"3D-printed medical implants will improve the quality of life of someone close to you. Because 3D printing allows products to be custom-matched to an exact body shape, it is being used today for making better titanium bone implants, prosthetic limbs and orthodontic devices. Experiments in printing soft tissue are underway, and may soon allow printed veins and arteries to be used in operations. Today’s research into medical applications of 3D printing covers nano-medicine, pharmaceuticals and even printing of organs. Taken to the extreme, 3D printing could one day enable custom medicines and reduce if not eliminate the organ donor shortage." (Source: Forbes: "Manufacturing The Future: 10 Trends To Come In 3D Printing").

A noter : un programme de don croisé de rein de son vivant sera introduit en France à partir de début 2013 (source : un médecin néphrologue de Strasbourg qui a confié cela à un de ses patients, lequel est un de mes amis FB ...). Cela fait un bon bout de temps que l'on en parle, de ce programme, qu'on annonce que cela va se faire ... et puis ... Voir un exemple ici, pour comprendre ce qu'est le don croisé :
"Irène a besoin d’une greffe de rein. Son mari Marc est prêt à lui donner un des siens, mais n’est pas biologiquement compatible. Le même problème se pose pour Marie, maman de Léa. Avec le don croisé, Léa pourrait bénéficier d’un rein de Marc et Irène d’un rein de Marie." (

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