Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Plier mais pas casser : la leçon de vie et d'entrepreuneuriat d'une Chinoise

Cette femme a connu le pire de la Chine, dans son enfance et sa jeunesse. Armée, travail à l'usine, coups, viol ...

Très jeune, elle est partie aux USA avec à peine de quoi s'acheter un billet d'avion, et la connaissance de trois mots d'anglais : bonjour, merci, au secours ...

Elle a participé à la mise au point du premier moteur de recherches sur l'Internet (Mosaic), est une pionnière en matière d'imprimantes 3D ... et conseille les startups les plus "glamour" aux USA - et même Obama !

Lisez son livre en anglais, "Bend Not Break", comme le roseau qui ploie mais ne casse pas, c'est passionnant ... 
"Bend, Not Break, by Ping Fu - exclusive excerpt": the "Personal Factory" concept:
 3D Printing, by a Chinese engineer:

"Born on the eve of China’s Cultural Revolution, Ping was separated from her family at the age of eight. She grew up fighting hunger and humiliation and shielding her younger sister from the teenagers in Mao’s Red Guard. At twenty-five, she found her way to the United States; her only resources were $80 in traveler’s checks and three phrases of English: thank you, hello, and help.

Yet Ping persevered, and the hard-won lessons of her childhood guided her to success in her new home­land.

Aided by her well-honed survival instincts, a few good friends, and the kindness of strangers, she grew into someone she never thought she’d be—a strong, independent, entrepreneurial leader.

A love of problem solving led her to computer science, and Ping became part of the team that created NCSA Mosaic, which became Netscape, the Web browser that forever changed how we access information.

She then started a company, Geomagic, that has literally reshaped the world, with 3D Printing."

==> "Bend, Not Break".

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