Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (


En parlant de 3D Printing ... Viens de voir le dernier livre de Chris Anderson (l'ex rédac chef de Wired) ... Livre intitulé : MAKERS the new industrial revolution ... Je vais m'y mettre ... Editeur : Random House Business Books (13 septembre 2012). L'impression d'objets et de matériau biologique grâce à des imprimantes 3D vous est inconnue ? Vous pensez qu'il s'agit de science-fiction ? Point du tout ... Suivez le guide (en anglais) ... Dans ce qui suit, on parle d'un "fablab" en Italie, mais il y en a aussi en région parisienne ... Il y en a une quinzaine en France, plutôt dans les centres universitaires ... Le "Fablab" est un endroit où l'on peut faire fabriquer les objets de son choix à l'aide d'imprimantes 3D ...

"The latest book from bestseller author and Wired's editor in chief Chris Anderson is dedicated to the Maker Movement, what has been dubbed as the [start of the] third industrial revolution.

If you never heard about Makers, 3D-printing, digital fabrication, Arduino, Kickstarter, and the new DIY movement, then this book is a great start (also check out the article The third industrial revolution by The Economist).

As in his previous books (The Long Tail: Why the Future of Business is Selling Less of More and Free: How Today's Smartest Businesses Profit by Giving Something for Nothing), Anderson does a great job in explaining a nascent trend in an easy language and with plenty of examples. Much of what he writes about is backed by his personal experience and through his access to key actors of the maker movement.

The book tells the story of the maker movement and compares it to the previous industrial revolutions, presenting the thesis that this shift in manufacturing could offer a way for the USA (and the Western world in general) to fend off the predominance of China in the production of physical objects. Anderson explains how manufacturing ('the world of things'), or more appropriately, digital manufacturing, is following the same steps as the Web, which has democratized publishing, broadcasting and communications, into the world of atoms, allowing almost anybody with a smart idea and a little expertise to make those ideas into physical objects.
*The Tools of the Maker Movement

Anderson describes the basic Maker tools -hardware and software- and their underlying technologies by dedicating a final chapter that describes such tools as:

-3D printers - additive processes like Fused Deposition Modeling (FDM) or Selective Laser Sintering (SLS)
-CNC (computer numerical control) machines - a substractive technology
-Laser Cutters (according to Anderson this is the 'real workhorse of the Maker Movement [...] they're the digital tool everyone uses first, in part because they're so simple and foolproof.')
-G-Code (the machine language used by 3D printers, CNC machines and others)
-Software like AutoCAD, Adobe Illustrator, Solid Works, Sketchup, TinkerCAD and many others.

*Making & Marketing


As a marketer, I found interesting the author's reflections on community building and marketing:
'When you're creating a community from scratch, consider starting it as a social network rather than as a blog or a discussion group. [...] One of the key elements of a successful community is content with broad appeal [...] such rich, engaging content is marketing -- marketing of the community itself, but also of the products that the community has created. Whether they thing of it this way or not, the most successful Makers are also the best marketers. They're constantly blogging about their progress, and tweeting, too.
Of course, it's not just marketing: the reason that it's so effective is that it's also providing something of value that people appreciate and pay attention to. But at the end of the day, everything you do, from the naming of your product to whose coattail you decide to ride (like we chose Arduino), is at least partly a marketing decision.'

Stop reading, make something

The natural step after reading Makers would be to, well, actually make something. I've been playing with Arduinos and have had access to laser cutters and 3D printers in the past, but never really engaged in a project. Now I've just joined the Fablab in Torino, Italy, for a practical introductory course to 3D printing and am working on a 2D design to run through a laser cutter, probably at the FabCafe (which as its name implies, is a coffee place with laser cutting machine and soon other maker tools) in Tokyo during my next visit (will report on that when it's done).


*Who is this book for?

If you're a maker already, this book will add little or nothing to your knowledge but it could be a great gift to offer to those that think you're kinda crazy and that you waste too much time tinkering at your workbench." (Source)

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