Precision Medicine will need to get out of the pharma silo that is based on symptoms

Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!

Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.

After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC ( to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (

2013: Year of the Water Snake

Here are some previsions for the Year of the Water Snake... I found them here...


"This is the tenth year of the Lower '8' Cycle of the world. Based on I-Jing, while the period between 1984 and 2043 (totaling 60 years) is 'Fire-Wind Urn', the year 2013 is 'Mountain-Thunder Rhythm'.

I-Jing Analysis'
'Mountain-Thunder Rhythm' contains 2 'Yang’s' to surround 4 'Yin’s'. While the outside seems to be solid, the inside is empty. Hence it is a year of conservation, a year of rebuilding and a year of changes.

Life Chart Analysis
This year is composed of 'water snake' year, 'wooden tiger' month, 'metal ox' day and 'earth rat' hour. While its year and month are in conflict, its day and hour connect. The year would begin with many uncertainties but end up on a high tune. There is an over-abundance of wood and fire, which become negative elements for the year. Elements of 'earth, metal and water' would serve the year better.
Flying-Star Analysis
The '5-yellow' star is the controlling force of this year. This sign is a very turbulent one. It would bring the world to extremities – good or bad. Its nature is 'earth'. Countries in both south and north would do better than those in the east or west. China would control to lead the world’s economy. Western countries would continue to suffer from economic instabilities.
The following would outline an analysis of orientations, businesses, politics, economies, climates and health, totaling 6 important factors affecting all of us.

2-Locations and Orientations
Central (positive and negative swings)
The controlling force is the central 'Earth-Mountain Humble' trigram. Earth above Mountain, with 3 Yin’s on top and 2 Yin’s at the bottom. Hence the central Yang gets to move around freely. This means the central country, i.e. China holds the controlling power of the world’s economy. However, with '5 Yellow' being the central control, there may be plenty of natural disasters, such as earthquakes and drought. Middle East countries would go through a period of extreme political turmoil. There would be a few major earthquakes, especially around Iran.
East (negative)
This is the '3-Blue' argument center. It is also the center for 'Triple Conflict'. There would be controversies and arguments around Japan, such as land ownerships. There would also be earthquake and volcano activities in the west part of the Pacific Ocean.
South-East (positive)
This is the '4-Learning' center, indicating advances in academic activities. On the positive side, it means outstanding scholars to come out there. On the negative side, many controversies may involve thinking and directions of learning. Representing places are Hong Kong, Taiwan, Florida (USA) and South Ontario (Canada). There would also be plenty of hurricanes and rainfalls in such areas.
South (half-half)
This is governed by the '9-Violet' which stands for happy events. Unfortunately, there would also be lots of fires and may even be drought. Representing places are Australia, South America and Africa.
South-West (negative)
This is the '2-Black' illness center. This could be the source of many illnesses. Places such as Tibet and Xinjiang in China, Spain and Portugal may have such issues. However, their political and economic situation may have to start from the basics.
West (negative)
This is the '7-Receding' center. West countries would be stuck with controversial policies. There would be distrust among countries. New governments had to search for new and more innovative solutions to their economies.
North-West (positive)
This is the '6-White' travel center, with wealth signs. North-Western China would be showing positive results in their economic developments.

3-Northern Europe would do much better than Southern Europe. Canada’s Alberta continues to be prosperous. More real estate developments would take place in north-western Toronto (Canada).
North (positive)
This is the '1-White' romance center. Canada and other northern countries would do well economically. There would be surprise opportunities for wealth. Breakthroughs in technology and medical research would happen.
North-East (very positive)
This is the '8-White' wealth center. However, it is also governed by the I-Qing of 'Mountain-Earth Corrosion'. Hence North-East places would experience big swings in economy and natural disasters. Japan would do well economically, but had to go through another round of natural disasters such as earthquakes. In Canada, for example, Quebec’s situation would once again become unstable. In USA, New York and Boston would see their economy greatly improve.
Analysis of Businesses
Business involving 'earth, metal or water' would do well. Those involving 'water or earth' had to work much harder. This is a year of instabilities, especially in both Middle East and Southern Europe.
Let us examine various businesses as follows.
Real Estate
There would be adjustments, but not bubbles. China would experience overall recovery, except both east and west parts of the country. After one year of some recovery, USA would go through another period of slowdown in real estate. Canada’s real estate market resumes its high note once again. In Toronto (Canada), Scarborough and Mississauga may slow down; but the rest of the city would be doing well. Vancouver (Canada) may experience further slides.
There would be a fair number of problems with energy, including leakage with nuclear power. Iran would continue to be a problem because of the nuclear issue. There would be many world issues related to oil and sources of energy. The good news is that there would be good energy deals between China and Canada.
There would be many changes of leaderships at the top, resulting in big swings in the stock market. There would also be many mergers.

4-Microsoft, Apple and Samsung would all do well. Google would come out with some new breakthrough products. Hewlett Packard, RIM and many traditional cellular phone companies may run into more troubles. Tablet computers would cover more and more of the laptop computer functions.
This is a year of many new forms of illnesses. The medical world would be very busy. Good news is that breakthroughs may happen in many health areas. However, in Canada, governments would attempt to cut back many medical expenses.
There may be food problems originated from the South-West and Central regions. However, food business would do well this year.
There would be big demands for industrial metal, such as copper and steel, especially in China. There would be breakthroughs in the development of new material for airplanes and automobiles.
This is a prosperous year for the travel industry, especially those involving water. Hence this would be a good year for the cruise boat industry.
The clothing sector is still in a low cycle. More and more famous brands would be made in third-world countries. Advanced countries may end up to be importers for their own products.
Banking and Financial
The stock market would continue to swing violently. There would be money to be made through mergers. More investment scandals may surface. The Euro would continue to hang on. Southern European countries may go through a period of stability. Hidden dangers would not go away as yet.
Analysis of Politics
The governing sign '5-Yellow', plus the central trigram 'Earth-Mountain Humble' indicate that the world would once again become unstable. There would be many power struggles. USA would re-focus more on South-East Asia. However, problems in Middle East would split its efforts.
Its overall direction would help to reap good results. Its economic progress would top most western countries. Besides its political stability, its relations with third world countries continue to improve.
It may re-use its 1960-70 international policies to enter the Pacific region. However, its internal economic situation may prove to be a retardant for the process.
There would be new policies to return to the fundamental value of the country. It would become the leader of many developing countries, especially Africa. There would be quite a lot of natural disasters, such as drought, flood and earthquakes.
6- Hong Kong: Hong Kong is in the learning center for this year. There would be outstanding scholars. However, there would be a lot of controversies related to education. Hurricanes and flooding would be plentiful too.
There would be continuous political arguments. There could even be political scandals. Nonetheless, Taiwan’s relationship with mainland China would continue to improve.
It is at the 'Triple-Conflict' and 'Argument' center. There would be political turmoil once again, both inside and out. Perimeter land ownerships would become big issues.
Economically, it would do very well and much better than most countries. Conflicts between South and North Korea may not be as severe as previous years.
Other Southern Countries
Countries such as India, Africa and Australia may enjoy some political stability but would be very hot and subject to many fire problems.
Other Western Countries
Many countries in Southern Europe would continue to suffer from their economic fallouts. Some may even threaten to pull out of EU. However, those in Northern Europe would be much more stable.
Middle East
This would be the most volatile region in the world for this year. They had to go through much political turmoil and natural disasters such earthquakes. Battles, if not wars, would continue.
Economically, Russia would do well. Gradually it would try to claim ownership of areas in the Arctic Circle and North of Japan.

Analysis of World Economy
The governing sign '5-Yellow' and its flying star sign of 'Earth-Mountain Humble' may force the world to go through more tests. The world may tend to take a more conservative mode in many policies
7-CHINA’s economic growth may slow down to around 8%. There would be advances in both North-Eastern China and Xinjiang’s development.
JAPAN suffers from the effect of 'Triple Conflict'. Its electronic businesses may be badly influenced. There would be recalls of automobiles. Although Japan’s overall economy remains strong, its growth would be much hindered.
KOREA is at the 'Wealth Center' this year. Samsung and Hyundai would continue to lead its economic advances. Its electronic sector, such as cellular phones and related items, would take a modified approach to combat Apple, thus confirming its number 2 position in the world electronics.
INDIA may suffer from its natural disasters, thus limiting its growth to about 3%.
USA’s economic recovery may have to go through some more stumbling blocks. Its astronomical debt and deficit prove to be a tremendous burden for the country. Both automobile and real estate sectors may prove to be the savior of its economy.
CANADA would continue to benefit from its influx of immigrants, especially those from China and Middle East. Its major bases continue be in the sectors of energy, natural resources and land development.
RUSSIA’s economy continues to be less affected by the rest of the world. It would continue to grow at a healthy pace.
EUROPE will once again confront new economic issues. Even leading countries such as Germany and France would run into trouble. Many countries’ leadership would run into great tests.
Central BANK interest rates would continue to stay low, world-wide.

8-Analysis of World Climates
There would be many natural disasters and irregular weather patterns. This could be a record year for the number of earthquakes. USA, in particular, would have many tornados in its Midwest region. Southern regions would be very hot and prone to fires. Hurricanes would be plentiful in South-East regions. North-Eastern regions would be more prone to earthquakes, including North Eastern China, Japan and Quebec (Canada). Flooding would occur in North and North-Western regions.
Analysis of World Health
Most illnesses could be due to food sources. Contagious illnesses related to the respiratory system would be common. The illness source would tend to be in the Central and South-Western regions.

The driving force of our planet Earth is continuous transformation of Yin (negative) and Yang (positive) energies and cycles. By knowing the rules of nature, we can avoid many pitfalls and have better chances to succeed. Hence I shall share these predictions with my readers around the world for reference and guidance."


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