Precision Medicine will need to get out of the pharma silo that is based on symptoms
Welcome to the digital era of biology (and to this modest blog I started in early 2005).
To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!
Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.
After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.
Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).
I love Genomics. Would you rather donate your data, or... your vital organs?
Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.
Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).
"Ape" ou comment publier son livre
Guy Kawasaki is the co-author of APE: Author, Publisher, Entrepreneur–How to Publish a Book with Shawn Welch. The book’s thesis is powerful yet simple: filling the roles of author, publisher, and entrepreneur yields results that rival traditional publishing.
"If you checked the list of what people want to do before they die, you’d see that many want to write a book. This is a good thing because the more people who write books, the more enlightened the world will become. It just so happens that technology has made the process of writing a book easier than ever. Still 'easier than ever' is not the same thing as 'easy.' I wrote a book called APE: Author, Publisher, Entrepreneur to help you write your book. Here are my top ten tips.
1. Write for the right reasons. Writing is an art form, and a book is an end in itself—don’t write a book solely because it is a means to an end. The good reasons to write a book are the desire to enrich people’s lives, to further a cause, to achieve an intellectual milestone, and to get something off your chest. The bad reasons are to make a lot of money or to increase your consulting or speaking business.
2. Use Microsoft Word. It’s true that Word is a bazooka, and you may only need a fly swatter, but everyone in the industry uses a bazooka. You can save a few bucks and avoid the Microsoft hegemony when you’re in the writing stage, but when lots of people (editors, reviewers, designers and online resellers) need to use your file, you may regret using another word processor. Two fine points: first, save your Word documents in the .doc, not .docx, format so that people using old versions of Word can open your file. Second, format your entire book using Word’s 'styles.' This will make layout and conversion much easier down the road.
3. Write every day. I’ve written twelve books. If you had asked me if I thought I would write twelve books back when I started, I would have told you that you were hallucinating. How did I do it? Writing a little bit every day. Don’t ask yourself, 'How will I ever get to 60,000 words?' because it will make the task seem insurmountable. Just write something every day—even if it’s only a paragraph. One day you’ll wake up, and your book will be done. If you wait for that perfect time when the kids are asleep and making straight As, you may never start (much less finish).
4. Build your marketing platform. The hardest part of making a book successful may be marketing (not writing) it. Unless you have a great publicist with a powerful publisher, you are the 'vice president of marketing' of your book. It takes a year to build a marketing platform, so get started at the same time as you’re writing. If you wait until your book is done, it’s too late. My recommendation is to spend two hours a day writing and one hour a day on Google+, Twitter, Facebook, or LinkedIn. 5. Start with a Kindle ebook. First, Amazon’s Kindle service might amount to 80-90 percent of your sales. If your book is successful on Amazon, it will succeed elsewhere. If it’s not successful on Amazon, it probably won’t succeed elsewhere. Second, start with the ebook format. If it takes off, then you may want to go to print. But there’s little reason to go to print immediately unless you are writing, for example, a photography book.
6. Tap the crowd. The crowd is a beautiful thing. It’s full of people who know more than you do and are willing to give of themselves freely and unselfishly. They will provide content ideas, editing, and word-of-mouth marketing. Don’t be afraid to ask for help. Many people will contribute to your efforts for the intrinsic joy of helping a writer. The crowd will help you finish your book, which is another reason to start building your platform immediately.
7. Hire a copyeditor. If you’re going to self-publish your book, the worst way to try to save money is by not hiring a professional copyeditor. Copyediting is a specialized and refined skill—to use a medical analogy, only a fool would self-diagnose and self-medicate in an emergency. The goal is to produce a book that is as good as, or better, than a book from a large traditional publisher. You cannot do this without a professional copyeditor.
8. Hire a cover designer. The second worst way to try to save money is by designing your book cover. Like copyediting, design is a special skill that takes years of training and practice. People are going to glance at a postage-stamp size image of your cover next to ten others on Amazon. You have less than a second to convince them to click on your book to learn more and read reviews. They won’t click unless your cover is effective.
9. Test your ebook. In a perfect world, what you upload from Word and what online resellers deliver as an ebook would match. Every page, image, line break, and font would be right. This isn’t a perfect world. The bugs and glitches that can appear because of the conversion process from manuscript to ebook will shock, depress, and enrage you. You need to test your ebook on every platform that people will read it on: computer, tablet, reader, Macintosh, Windows, Android, and iOS. Don’t assume that any conversion process is 100% accurate.
10. Never give up. There are qualities that every published author shares: first, they wanted to give it all up. Second, they didn’t give it all up. Writing a book is one of the most difficult tasks in life. Fortunately, or maybe because it’s so difficult, it is also one of the most rewarding tasks in life. When you feel like you can’t type another word, can’t re-read another draft, and can’t face another rejection, remember that every author goes through these phases. It’s only the successful ones who never give up." (Source)