Scientific MOOCs follower. Author of Airpocalypse, a techno-medical thriller (Out Summer 2017)


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


I am an early adopter of scientific MOOCs. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs? Imagine all the people sharing their data...

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Airpocalypse

Illustration by Florence Cartozo
My medical thriller Airpocalypse will soon be out (French version first). Link to the lyrics for 8 songs I wrote (English) for this fiction: http://ethictransplantation.blogspot.fr/2016/12/crush-test.html

Ninth song: Airpocalypse 


Whenever I have
To wear a breathing mask
In Beijing,
I try to remember this.

Sulfate is a big contributor 
To the fog in Beijing, 
Sulfuric acid particles are formed
From sulfur dioxide, 
Released by coal burning 
For residential use and power plants.

Sulfur dioxide is turned
Into sulfuric acid. 
This deadly process 
Is facilitated by nitrogen dioxide, 
Another co-product of coal burning, 
And occurs initially on natural fog. 
Sulfur dioxide turning into sulfate 
Produces acidic particles. 
The sulfate formation process 
Is only possible 
With ammonia to neutralize the particles.
Natural fog contains larger particles 
Of several tens of micrometers in size, 
(In Beijing the haze starts 
From much smaller nanoparticles)
And the acid formed is sufficiently diluted. 
Evaporation of those fog particles 
Then leave smaller acidic haze particles 
That cover the city.

In China, sulfur dioxide
Is mainly emitted by power plants, 
Nitrogen dioxide is from power plants 
And automobiles, 
And ammonia comes 
From fertilizer use and automobiles.

The right chemical processes 
Have to interplay for the deadly haze 
To occur in China. 
Chinese haze is basically neutral
But it is not neutral to my health.

So whenever I have
To wear a breathing mask
In Beijing,
I try to remember this.

My health is left
Hanging in the air
Airpocalypse
Arpocalypse

Persistent poor air quality 
Often requires people 
To wear breathing masks 
During much of the day.

How about solutions?
Reduction in emissions 
For nitrogen oxides and ammonia 
Is likely effective in disrupting 
This sulfate formation process.

How about solutions?
My health was left
Hanging in the air
Airpocalypse
Airpocalypse

Reduction in emissions 
For nitrogen oxides and ammonia 
Is likely effective in disrupting 
This sulfate formation process.

So here’s my new 
Super duper
Scientific song
To pitch the UN
With brilliant ideas
To solve OMG
The air pollution
The air…
-pocalypse.

My health is left
Hanging in the air
Airpocalypse
Airpocalypse

And please don’t forget
Small particles between 2.5 and 10 microns
When measuring air quality,
Are just as deadly
As particles above 10 microns.

I know it’s a dream,
But just imagine.
Want a microorganism that eats 
Carbon dioxide 
And makes fuel? 
Someday you might be able
To point and click 
And get one delivered.

Engineering biofuels 
With the help of bacteria
In the lab, 
This will replace oil and coal. 
Tata India and Jack Ma China
Combining biofuels and solar energy
For the first zero carbon-emission plane flight.

I know it’s a dream,
But just imagine.

Here’s my new 
Super duper
Scientific song
To pitch the UN
With brilliant ideas
To solve OMG
The air pollution
The air…
-pocalypse.

My health is left
Hanging in the air
Airpocalypse
Airpocalypse

Biofuels using 
Synthetic biology. 
Optimizing the microbes for high-yield, 
Efficient production through 
Genome engineering, 
Matching the microbe 
With appropriate feedstock molecules 
Or micronutrients, 
And then fine-tuning the entire production process
For generating clean fuels 
That are drop-in ready for use 
In the gas tank at costs 
That are competitive with those 
Of natural petroleum products.

And now we did not think 
We were able to produce 
A flammable liquid 
In such a simple way, 
From electricity. 
Ethanol in place of oil. 

In an engine, ethanol is burned. 
This gives carbon dioxide and energy. 
In the factory, the carbon dioxide 
Is captured again 
In order to re-cycle. 
This way of storing electricity
In liquid form 
Is very interesting. 

So here’s my new 
Super duper
Scientific song
To pitch the UN
With brilliant ideas
To solve OMG
The air pollution
The air…
-pocalypse.

My health is left
Hanging in the air
Airpocalypse
Airpocalypse

And now we did not think 
We were able to produce 
A flammable liquid 
In such a simple way, 
From electricity. 
Ethanol in place of oil. 

Oil is the result 
Of photosynthesis 
Millions of years ago.

Trees have grown, 
Captured carbon dioxide 
Through photosynthesis. 

Plants retain carbon and release oxygen. 
Photosynthesis
Means that plants keep the sun, 
Which is the energy that breaks CO2 
Or carbon dioxide
Into carbon on one side 
And oxygen on the other. 
CO2 is a very strong molecule, 
C and O2 are bonded very strongly. 
It takes a lot of energy 
To break this molecule. 
Burning carbon makes it possible
to associate again 
C and O2, 
Carbon and oxygen, 
And releases energy, 
That was previously 
stored in C and O2. 

Energy is not lost 
And is not created. 
It can only be stored or free.

When separating C and O2, 
Energy must be provided 
To separate them. 
When we associate them again, 
This energy is released. 

Think about magnets. 
They are glued to one another 
And it takes energy to separate them. 
Once they are separated, 
It is as if they were storing 
A lot of energy. 
If we bring them closer, 
They will jump over 
Each other and stick together. 

Energy is not lost 
And is not created. 
It can only be stored or free.

The same applies to carbon and oxygen. 
If we have succeeded 
In separating them and then 
Bringing them together, 
There is energy 
That will be released. 

The problem with oil 
Is that photosynthesis 
Took place millions of years ago, 
So it removed a lot of carbon dioxide 
From the atmosphere, 
Which is rich in oxygen. 
Other forms of life 
Have therefore appeared, 
And require oxygen. 
When burning oil, 
Carbon dioxide and energy 
Are produced. 
The released carbon dioxide
Is not consumed, 
Because it is released 
Massively. 
The problem? 
we can see it right away. 
We do not make oxygen. 
And we have a big excess of CO2. 
That's what happens when the trees were burned 
Millions of years ago: 
We do not make enough oxygen 
And we have a large excess of CO2.

So here’s my new 
super duper
scientific song
To pitch the UN
With brilliant ideas
To solve OMG
The air pollution
The air…
-pocalypse.

My health is left
Hanging in the air
Airpocalypse
Airpocalypse

The effect of this carbon dioxide
is to isolate the atmosphere 
and create a greenhouse effect. 
And to acidify the oceans. 

Instead of burning oil 
That can not be duplicated,
We can burn ethanol, 
Which we can reproduce. 
As a result, oxygen is re-circulated 
In the air and CO2 is captured 
Again. 
Bye bye, big excess of CO2. 

The storage of energy 
Called photosynthesis
Can be done with ethanol. 
Then we do not produce carbon and oxygen, 
But ethanol. This can return 
To making carbon 
And oxygen, C + O2. 
C is coal, carbon, wood. 

The pollution in Beijing
Is linked to chemical reactions 
With the atmosphere 
Under certain conditions, 
When combustion of coal happens.
The reaction between carbon and oxygen 
Releases plenty of polluting compounds.

A diesel engine produces solid 
(and non-liquid) 
Microparticles. 
Solid Microparticles 
Have far more health effects 
Than the gases themselves. 
This micro-dust, 
When it enters the lungs, 
Remains there. 
This is also the case for asbestos, 
Which is also a micro-dust. 
In the case of asbestos and diesel, 
It is the accumulation 
That is bad for your health. 
Alcohol is even more refined than petroleum, 
So there are even less odors and soot. 
In the case of diesel, combustion particles 
Produce even more soot than in the case of oil.

So here’s my new 
Super duper
Scientific song
To pitch the UN
With brilliant ideas
To solve OMG
The air pollution
The air…
-pocalypse.

My health is left
Hanging in the air
Airpocalypse
Airpocalypse

So just imagine
Microbial factories for everyday products
Biosensors for food pathogens
Marijuana without the plant
Fixing your genes to cure diseases
The end of synthetic nitrogen fertilizers
And please remember:
Y cancer =f(X pollution lifestyle)

And even fancier:
Know the super-power
Of urine.
From the urine, 
We can reconstruct 
Stem cells of neurons 
(Folks, this means the death of brain death!)
And other undifferentiated stem cells.
The urine also serves 
For the production 
Of hydrogen 
For the cars of tomorrow.

That was my new 
Super duper
Scientific song
To pitch the UN
With brilliant ideas
To solve OMG
The air pollution
The air…
-pocalypse.

My health is left
Hanging in the air
Airpocalypse

Airpocalypse

I know it’s a dream,
But just imagine.
Want a microorganism that eats 
Carbon dioxide 
And makes fuel? 
Someday you might be able
To point and click 
And get one delivered.

My health is left
Hanging in the air
Airpocalypse
Airpocalypse.

Tenth song: Forget Yesterday Remember Tomorrow

Beijing’s sick beating heart
Witnessing pollution
And organ trafficking.
Beijing’s vibrant scientific scene,
Engineering, editing, making and hacking,
Trying to forget yesterday, 
Remember Tomorrow.
Engineering biofuels 
With the help of bacteria
In the lab. Making new drugs 
With the help of gene
Editing tools.
Forget Yesterday 
Remember Tomorrow.
Beijing’s recovering beating heart,
But…

Science is hype is money
I am a buzz word trader
The biggest Ponzi scheme ever
Nothing is forever
Going global, spinning faster
Burnout’s the new pot o’honey
People have started dating their innernet:
«  - Dear pitch-perfect A.I., will you be my Scarlett? »

Science happens by accident
A fungus remote-controlling the insect brain 
leads to . . . cyclosporine, 
The drug allowing physicians to transplant organs.
If the patient’s got an accident,
Doctors will look for the necrosis in his brain
Then another patient gets a new heart.
Medicine also happens by accident.
Is this incremental? Is this exponential?
Wait. I’ll ask the blockchain.
Women’s breasts and organs
Are political objects
In the database of Business Abject.
Digital locks and Rights Management
Are the new stethoscope of madicament,
I mean medicament.

I work in life science
I’m a buzz word trader
Accident is the new blockchain,
Making big data’s head spin.
Human on-a-chip
Hope-hip
I work in life science
I’m a buzz word trader
Accident is the new blockchain
Making big data’s head spin.
I am a buzz word trader
I deal emotions
One keynote at a time
Human on a chip
Hope-hip

Beijing’s anonymous heartbeat,
Hacking into the Operating System
Of Humanity
Writing snippets of code
Encoding more equity
Into the language of evolution
Yeah, revolution, evolution, devolution, religion
You decide.

They call me Anonymous
But that’s just what I write
When asked for my identity
While downloading a file
From some FTP server.
I’m a geek I’m a hacker
And maybe some day
Some anonymous organ donor.
I guess this is the reason
Why they call me Anonymous.

Free and anonymous
I am,
Just like organ donation.
We don’t need more anonymous
Prisoners executed, 
Slaughtered
For their hearts kidneys lungs
Sold for medical transplants.

Bloody Harvest 
Bloody Harvest 
Beijing’s beating heart 
Is bleeding.

We need more gene editing science.
The science of vital organ replacement 
Is paved with accidents and crisis.
Now we need to edit that crisis out
And make amendments thanks to a cool
Crisis editing tool,
Sorry I meant,
Gene editing tool.
Yeah, revolution, evolution, devolution, religion
You decide.

Forget yesterday,
Remember tomorrow.

Hey, rest of the world,
Listen to what China has to say.
Just like the low-cost flight company:
« If you are late, we won’t wait ».
Forget yesterday,
Remember tomorrow.

Beijing’s beating heart,
Telling me what Anonymous means.
It means anyone.
ANYONE 
Can go from concept to execution 
Of coded proteins 
Virtually overnight, 
Through cloudlabs, 
Robot lab assistants, 
And rapid prototyping software. 
Cost is dropping fast. 
Direct-build-and-deploy your personal
– Medicine Farm
– Nanofactory
– Liquid biocomputer

Forget yesterday,
Remember tomorrow.

How about a nice, graphical, 
Web-accessible SaaS 
For compiling genomes, 
With direct printing of DNA 
Via your cloud lab of choice?
'Shapeways for genes' has arrived.
Have fun with the 'mutate random amino acid' function!

Here is gene therapy’s Secret Recipe
(yes I love their raspberry cheesecake too):
Take an adeno-associated virus 
Devoid of toxicity
(typically AAV9) 
In 20% of cases, when you have a sore throat 
It is this type of virus, therefore no sorcery
And introduce corrective action 
Using Crispr / Cas9 
Such that if the virus is swallowed / injected 
It will 'infect' cells 
With the consequence 
That if there is a DNA sequence 
AATCGCGGCGAGCGAG 
(I just made up that one) 
It will be replaced with AATCGCAACGAGCGAG 
Where the central GG
Is replaced by AA,
And trust me 
This should be
No ‘mutate random amino acid' function.

Beijing’s lungs are struggling to breathe
Airpocalypse
Airpocalypse
Lung cancer represents
Two deaths every minute
Worldwide.
So please Airpocalypse xiānsheng,
Don’t tell me bioengineering
Cannot help.

Beijing’s ailing lungs on-chips,
Engineering biofuels 
With the help of bacteria
In the lab.
Want a microorganism that eats 
Carbon dioxide 
And makes fuel? 
Someday you might be able
To point and click 
And get one delivered.

Forget yesterday,
Remember tomorrow.

I work in life science
I’m a maker
Evidence is the new blockchain,
Big data crunching
Snippets of Computer Code
For Human Organs-on-Chips,
Clinical trials going digital 
And exponential.
Big data means
Prices are dropping.

Forget yesterday,
Remember tomorrow
This is Beijing’s beating heart
Sole credo
I can hear it now.

Forget yesterday,
Remember tomorrow
This is Beijing’s beating heart
Sole credo

I can hear it now.

Lyrics of all songs by Catherine Coste, for medical thriller "Airpocalypse". Copyrighted material.

#GenomicEntertainment

Crush Test


Crush Test is the name of my new band. I'm the singer and my friend & publisher, Jon, is the musician. Well, he's been playing electric guitar and classical guitar for 40 years ;-)

I've been asked to write lyrics for songs, related to my fiction (a medical thriller) Airpocalypse. This fiction will be out soon (Fr version). The songs are all related to the fiction. The main character is Lenoir, a French cardiac surgeon, having made mistakes in the past, trying to implement the future of medicine, in France but also in China (Beijing). Lenoir will experience an epic breakup with his secretary, Mia, then he gets to meet with a scientist from China, a microbiologist and bioinformatician, Eileen Li.

This is the first song we are working on (The Mad Tear Party), and here is the second one (Cell Haiku):

Brain
Is Cell biology
Is molecular biology
Is genetics
Is a powerhouse
for microbes.

Computer science
Is medicine.

Python R Statistics MATLAB
Are tomorrow’s
Microscope
Stethoscope.

Genomics
Is making medical diagnostics.
Gene editing tool
Merry CRISPRmas
Is the new scalpel.

Left hand
Is for the wet lab
Right hand
Is for the dry lab.

Computer programmer
Is the new Doctor.

Science
Is Medicine
Is Data is data is data.

Citizen science
Is a MOOC
Is Decentralized Medicine.
Dying Steve Jobs:
« Biology and I.T. have merged.
Time to learn about it. »

Genomics
Is making medical diagnostics.
Gene editing tool
Merry CRISPRmas
Is the new scalpel.

Left hand
Is for the wet lab
Right hand
Is for the dry lab.

Computer programmer
Is the new Doctor.

Third song: My biochemical romance

I am an IT & Cell Architect
Circuitry of human cells
Analog to
Digital technology.

I am a maker
With a biocomputer.
Chip on your shoulder?
Put it in a cell. Human on chip.

Yesterday I grew
Snippets of code
From my RNA.
When I grow old
Snippets of organs
Will grow
From my DNA.

« I want you to engineer a molecule. »
My body cells
Coding in
Python.

I am a maker
With a biocomputer.
Chip on your shoulder?
Put it in a cell. Human on chip.

Love as
A mechemical
Hub.
Snippets of bugs,
Code on fire, hug & mug:
Snug bucket list
Of chemicals
Scripting in Java
C++ Signature Claws
Of Schrödinger’s cat
Speaking snake language
Phishing lies
Fishing apples.

I am a maker
With a biocomputer.
Chip on your shoulder?
Put it in a cell. Human on chip.

The sun
Will learn
From my
Mitochondria.
DNA
Replicating in
The Social Network.

I am a maker
With a biocomputer.
Chip on your shoulder?
Put it in a cell. Human on chip.



Fourth song: If Mister Spock Could See Me

Luxury brands investing in biotech
Patenting 365 biochemical and genetic pathways
That are responsible for calmness, happiness and sensuality.

If Mister Spock
Could see me

As I have
No God no Religion
He would say
I am not a good companion.

Luxury brands investing in biotech
Patenting 365 biochemical and genetic pathways
That are responsible for calmness, happiness and sensuality.

As people
I admire most
Are dancers
Choreographers, writers;
Not scientists,
He would say
I am an escape artist.

Luxury brands investing in biotech
Patenting 365 biochemical and genetic pathways
That are responsible for calmness, happiness and sensuality.

My faulty logic,
My love for Edgar
Allan Poe,
My woe...

All
A minor
Mishap.

A grave
Misunderstanding,
When it comes to my
C Sharp
Or Python coding.

Luxury brands investing in biotech
Patenting 365 biochemical and genetic pathways
That are responsible for calmness, happiness and sensuality.

If Mister Spock
Could see me

His diagnosis
And Freudian logic
Writing an algorithm,
A sci-fi beam,
A beating-heart
Force bypass.

If Mister Spock
Could see me

May the Force
Be with my coronary artery.

His diagnosis
And Freudian logic
Writing an algorithm,
A sci-fi beam,
A beating-heart
Force bypass.


Fifth Song: The snapdragon flower on the Great Wall

The mistake I once made
Kept popping in my head
Driving me backwards
Driving me too far
Deep learning connecting
Her tears with my blood.
Her blood with my tears.

Forwards was always
Made of walls,
Of whispering 
Shards of mirror, 
Taking my blistered heartbeats
On a shoestring
On the Great Wall,

Made-in-China 
Grief.

I am a cardiac surgeon
I play it by ear
Never by the book.

My mistakes whispering to me:
« You belong to the past »
All day long
Shoestring by shoestring
On the Great Wall.

She was there she witnessed
Everything
And yet she knows nothing.
My heart is not this ice bucket
That we both know
Like the back of our hand.

Our love came to grief.
« Let-It-Go » Princess
Throwing walls
Analyzing the bricks’ DNA
Saying « Ha it’s all yours! »

And my mistakes whispering to me:
« You belong to the past »
All day long
Shoestring by shoestring
On the Great Wall.

Our epic breakup
Is still echoing
On The Great Wall.
Our Terracotta love,
Made in Xi’An,
Guarding the walls
Guarding the tombs.

Among the soldiers,
I saw hidden lotus flowers.

« Can’t you see
This army
Is only 
An army 
Of garden 
Gnomes? »

It took me some time,
But I grew to like
Their whisper.
I made sure
It would pave
My own way.
I grew out of grief.

I grew to love
Their whisper.

This garden gnome
Slayer
Was a bioengineer
From Beijing.
I replaced frontiers
With sciences,
Infinite Loops
That kept me in the past
With the most unexpected thing:
A bunch of fresh flowers.

Seeking their freedom
I forget that Xi’An past.
The science and love we make
Make me forget
The walls in my blood platelets.
I am from Beijing
I am from Paris,
Who cares?
The walls have ears,
But our science
Won’t stay in its niche.

I am a cardiac surgeon
I play it by ear
Never by the book.

Our science is going glocal.
Our science is our frontier,
Garden gnomes travelling
Around the globe.
They forgot the taste of
Terracotta,
They are not sure
If it is panacotta
Or mozzarella.

I am a cardiac surgeon.
There was this time
When walls were reaching deep
Into the roots of my nerves,
And I was addicted to cheese…
… cheesy love.

I am a cardiac engineer.
Now it’s time
For the dragon and the lotus flower
To meet.
To meet forever.

Forever trying to understand,
Binding stone with living material
That will heal the building
During earthquakes.
Bioengineers helping
Walls to heal…
The Great Wall is coming to life,
It stayed dormant too long,
And forgot
That it was a dragon.

I am a cardiac engineer.
Now it’s time
For the dragon and the lotus flower
To meet.
To meet forever.

Beijing love.

When the dragon found out
That sitting by the horrendous fire
he was spitting and breathing
There was
This industrious snapdragon flower,
Mocking him 
Because he was suffering
From Garden gnome anxiety.

Beijing love.

When the dragon found out
That sitting by the horrendous fire
he was spitting and breathing
There was
This industrious snapdragon flower,
Mocking him 
Because he was suffering

From Garden gnome anxiety.

Sixth Song: Girl With Golden Genes





I met with her
When i was sitting'n 
Sinking
Deep down 
In the nick.

Reliving again and again
Forced organ
Transplant'n
Harvesting
In China.
Made-in-China 
Organs.

She arrived in the nick of time
Or so I thought.
She is a scientist
Her questions are like her genes:
Dangerous.

« Why can’t humans regenerate body parts? 
We’ve got the genes. »

Her questions are like her genes:
Dangerous.

I am a transplant surgeon.
I do bypass procedures.
Didn’t she just say
She wants to bypass me?

Her questions are like her genes:
Dangerous.

« Why can’t humans regenerate body parts? 
We’ve got the genes. » 

My dreams must have materialized
This hazard
So beautiful I couldn’t begin to imagine Her.
Us.
She laughed and said
She was a woman; not a question,
She said she was an engineer in Beijing
With a startup 
« Life at the speed of light »:
She was able to digitize living material
And e-mail
It to me.
« And flip that round:
You e-mail me living material
And I rebuild it in the lab.
As good as new. »

Then she asked again:
« Why can’t humans regenerate body parts? 
We’ve got the genes. »

« Who are you?
Digital life? », I asked.
Was she just an e-mail 
I had received in the nick?

She arrived in the nick of time
Or so I thought.
She is a scientist
Her questions are like her genes:
Dangerous.

The queen of digital life
Made my body parts
Feel more alive than ever
All of me in all of her.
Our love was a digital
Grinning cat,
But then we met,
In rainy Beijing,
In the deadly fog
of a bitter cold winter.

Now I have a crush on her
Startup.
Now I want to love at the speed of light.
« Are you talking about
body part regeneration? »
She asked.

A surgeon and an engineer
Drinking from the same cup
In Beijing’s Airpocalypse.
Making love and science,
At the speed of light.

I could hardly breathe.
« How about air at the speed of light? »
I asked.

« We’ve got a lot of genes
To regenerate our lungs,
Or limbs or heart »
« - Yes but something
isn’t allowing
That to happen.
That something is evolution.
For some evolutionary reason, 
this process has been blocked off.
our immune systems spoil the party 
by building up scar tissue around cuts. »

« Through DNA, every cell in our bodies 
contains the roadmap 
to build or re-build 
the entire machine. »

« if we can figure out 
how to turn on these genes, 
we can regenerate »

I said: « - You turn me on. »
Then paused.
No. Wait.
She had just flipped 
The switch.

« Do you want
To yank off hearts
From half dead prisoners 
in Beijing winter
Forever? »

She arrived in the nick of time
Or so I thought.
She is a scientist
Her questions are like her genes:
dangerous.

« - I just want to breathe »

She arrived in the nick of time
Or so I thought.
She is a scientist
Her questions are like her genes:
dangerous.

Her. At the speed of light:

« There must be
some sort of 'master control' gene
that starts the process off.
This could have implications
For central nervous system, 
heart and other internal organs
regeneration. »

She arrived in the nick of time
Or so I thought.
She is a scientist
Her questions are like her genes:
dangerous.

Her. At the speed of light.
" - Could this be an accepted medical reality in 100 years?"

She arrived in the nick of time
Or so I thought.
She is a scientist
Her questions are like her genes:
dangerous.

Her. At the speed of light.
" - Could this be an accepted medical reality in 100 years?"

Seventh Song: The Uighur Who Was Looking For The Bismillah Of DNA And Ended Up With A Nobel Prize

In the medical thriller "Airpocalypse", Jian Ping is a "dissident" writer living and working mainly in Beijing. Two pieces of fiction he wrote (one on organ trafficking, one on pollution) will land him in (and eventually out of) jail. Even though the surgeon part (Lenoir) has been written for Spanish actor Jean (Mo)reno -- so of course Lenoir is at the centre of everything -- Jian Ping is my favorite character, the one who kept me wanting to write this story, that in fact is his story. 

Jungle Genomic Book
3 billion base pages 
Of As, Ts, Cs and Gs 
Not informative.

3 billion phenotypes:
Holy Grail

Big Pharma 
One Blockbuster.

New tool
For evolution
Found
In ancestral species:
RNAs.

3 billion phenotypes:
Holy Grail.

Big Pharma 
One Blockbuster.

Genes replicating,
Expanding,
Travelling without moving.

At the beginning 
Of life:
No Copyright Infringement
Madness. 

Lawyers:
Nucleic acid
Replicating machines,
Viruses
Wreaking havoc. 

3 billion phenotypes:
Holy Grail.

Big Pharma 
One Blockbuster.

At the beginning
Of life:
RNA Interference Madness.
The cop
Protecting « Purple » 
Killing « Elprup ».

Mirror images:
Vade retro,
Omnia Vanitas 
Virus.

3 billion phenotypes:
Holy Grail.

Big Pharma 
One Blockbuster.

Evolution with cop:
Cutting through proteins.

Doctor's stethoscope, 
Out of Patient's scope,
Has fallen into disuse.

Blockchain and Smartphone, 
Playing Doctor on 
Periscope.

I am a Uighur
Looking for the Bismillah of DNA
I am looking for the Bismillah
Of DNA 
Of RNA
The Sunnah of Biology

They say
DNA makes RNA makes Protein
The Sunnah the better

The Sunnah you understand
Biology
The better.

Looking for the Bismillah of DNA
I found viruses
RNA viruses
Their genomes are made of RNA
But they eventually
Make a copy
A DNA copy
Of their RNA genome
And integrate it
Into the host 
Organism.

Looking for the Bismillah of DNA
The Sunnah of biology
I discovered 
This is the first time 
The central dogma
Ever went backwards.

The Bismillah of DNA
Is not as dogmatic
As we originally thought -
Looking for the Sunnah of Biology
I ended up with a Nobel

Prize.


Eighth song: Wrong Hands. 
In my medical thriller "Airpocalypse", there is a dialogue between a pair of AR/VR glasses and Lenoir, a French cardiac surgeon, senior member of the Académie of Medicine in Paris, going to China to transplant hearts. Like those little vials or flasks that are labelled "Eat me" or "Drink me" in "Alice In Wonderland", the pair of glasses is conveying a message: "Wear me."

(AR: augmented reality
VR: virtual reality.) 

I’m a tiny
Big Data
Device,
About the size 
Of a pair of glasses.

I see the future
In Virtual Reality.

Organ transplant in China?
They say:
Free will, 
Morals and responsibility,
But in the territory
Of democratorship.

I say:
Genes, hormones and neurons 
Merely comply 
With the universal laws 
Of physics and chemistry. 
An electrochemical process 
At work in the brain, 
Because of this or that genetic profile 
Resulting from constraints 
Resolved in such and such a way 
By evolution.
Add a pinch of epigenetic, 
These mini conductors of our chromosomes 
Making proteins, 
And of course some mutations 
Due to chance, 
Happy or deleterious.

See, biology and I.T.
Have merged.
Time to learn about it.

Environment
And wrong hands.
Transplant surgeons,
Know where your organs come from.
Use me.

If this heart is from a Falun Gong Spy
Arrested by the Chinese Army,
Or from the mafia
Trying to steal 
The Falun Gong’s money,
Or from Uighurs,
People from the 
Muslim Republic of China
In Xinjiang
Sitting right next to
The territory of
Daesh,
I will show you.
See, biology and I.T.
Have merged.
Time to learn about it.

Environment
And wrong hands.
Transplant surgeons,
Know where your organs come from.
Use me.

Nobody wants the heart
That triggered
The war.

If the mafia 
Or the Uighurs
Want to take revenge on
The surgeon 
Who took their hearts,
I will show you.

If Northern Korea
Wants to make an alliance
With Daesh,
I will also warn you.
But don’ worry
Secret Services
In China
Are already on it.
They will break this alliance
At all costs.

Nobody wants the heart
That triggered
The war.

Daesh with nuclear 
Weapon,
Willing to
Restore the Caliphate.

I will tell you
Where this heart is from.
Nobody wants the heart
That triggered
The war.

Know
The DNA of geopolitics,
The environmentalome.

A Uighur
Is a person from 
The Xinjiang province,
A Muslim Chinese.

Know
The DNA of geopolitics,
The environmentalome.

Is organ donation
The donation
Of nuclear weapon
To Daesh
Because of transplanted hearts,
In an obscure chain
Of causes and consequences?

Organ donation
And donation of
Nuclear weapon
Are two different things.

Nobody wants the heart
That triggered
The war.

Dead angles
That doctors cannot see,
Organ transplant in wrong hands,
I will show you.

Genes, hormones and neurons 
Merely comply 
With the universal laws 
Of physics and chemistry. 
An electrochemical process 
At work in the brain, 
Because of this or that genetic profile 
Resulting from constraints 
Resolved in such and such a way 
By evolution.
Add a pinch of epigenetic, 
These mini conductors of our chromosomes 
Making proteins, 
And of course some mutations 
Due to chance, 
Happy or deleterious.

See, biology and I.T.
Have merged.
Time to learn about it.

Environment
And wrong hands.
Transplant surgeons,
Know where your organs come from.
Use me.

I’m a tiny
Big Data
Device,
About the size 
Of a pair of glasses.

I was a device;
I became a software.

I see the future
In Virtual Reality.

Biology and I.T.
Have merged.

Time to learn about it.

Lyrics of all songs by Catherine Coste, for medical thriller "Airpocalypse". Copyrighted material.

#GenomicEntertainment

Docteur Uber

Par Jean-Michel Billaut
Si je n’étais pas coincé
Dans ce silo 1.zéro
J’aurai bien rigolé
Mais c’est pas de pot
Nos elites en sont toujours à des batailles d’égo
Jamais on va s’en sortir

Allez, j’aime autant en rire.

Je passe une grande partie de mes journées
dans le e-walhalla Internet,
qui me permet de m'informer 

"Imaginons l'accès à l'innovation". 
Base line : "Connectons l'innovation aux patients et à leurs besoins"
Rien que cela.. 
Qui doit connecter quoi ?
Médecins, mandarins, présidents d'associations de patients, sachants de tout bord, etc.
Belle cohorte du monde médical français.

brainstorming
brainstorming
brainstorming
Tempête sous un crâne

Alors j’ai pris le micro
" Mesdames Messieurs, 
j'ai l'impression d'assister 
à une réunion syndicale 
de chauffeurs de taxis, 
AVANT l'arrivée d'Uber.. 
Avez-vous bien conscience que Docteur Google 
et tous les autres, 
si vous continuez de vous recroquevillier 
dans vos différents silos 
et à ne pas vous informer sur ce qui se passe ailleurs, 
que ces Gafa, donc, vont vous passer dessus ?"
Les Gafa vont nous passer dessus
Gaffe, les gafa vont nous passer dessus

"Ce sont les Français, 
et notamment nos milleniums, 
qui vont adhérer à la santé prédictive 
prônée par le Président américain, 
sur le cloud e-santé d'Apple ou d'IBM ?" 

Gaffe aux Gafa
Les milleniums 
vont vous laisser tomber.

Gaffe aux Gafa
Les milleniums 
vont vous laisser tomber.

"De nombreux Français aujourd'hui 
utilisent les VTC, 
délaissant les taxis 1.0 
Vous aurez l'air fin ! 
De nombreux Français aujourd’hui
vont vous laisser tomber.

D'un côté les Gafa 
qui en sauront plus que vous 
à brève échéance 
sur les SCIENCES 
médicales alors que vous 
ne pratiquez qu'un ART 
malgré vos 10 ans d'études, 
et de l'autre votre "clientèle" 
que vous pensez captive, 
et qui n'hésitera pas 
à vous quitter pour de meilleurs services, 
MOINS chers... !
23 € en contrepartie des 15 minutes 
que les médecins passent en moyenne 
avec leurs patients..."

"on n'a pas le temps de faire de l'empathie", 
on a aussi appris que certains présidents 
d'associations de malades 
voudraient se faire rémunérer, 
que le numérique n'est qu'un outil (ton dédaigneux),
que l'humain c'est vachement bien 
(mais pas trop quand même, car l'empathie n'est pas payée)

"Mesdames Messieurs, 
j'ai l'impression d'assister 
à une réunion syndicale 
de chauffeurs de taxis, 
AVANT l'arrivée d'Uber."

"J'ai aussi fait remarquer, 
qu'ayant passé 7 mois dans le système de santé 
français.. suite à mon amputation, 
que ce grand barnum 
pourrait nettement mieux s'organiser 
avec les technologies disponibles aujourd'hui 
le cloud, le Saas, l'intelligence artificielle.

On pourrait stopper les bisbilles 1.0 entre le silos des blancs 
le Samu, 
et le silos des rouges 
les pompiers
entre les médecins et les pharmaciens.

Bref si vous voulez mon sentiment : 
un gros foutoir 1.0."

Bref si vous voulez mon sentiment : 
un gros foutoir 1.0."

Si je n’étais pas coincé
Dans ce silo 1.zéro
J’aurai bien rigolé
Mais c’est pas de pot
Nos elites en sont toujours à des batailles d’égo
Jamais on va s’en sortir

Allez, j’aime autant en rire

"Il faut vous informer sur ce qui se passe dans le village planétaire.."
Et j'ai expliqué 
que nous allions passer du curatif au prédictif, 
et que l'avenir serait moins à la chimie et à la molécule 
et plus à la data.. 
Mais pour cela, il faut que tous ensemble 
nous mettions nos données de santé on line.. 
de façon à découvrir avec le big data et l'intelligence artificielle, 
les mécanismes du cancer et autres saloperies.. 
les mécanismes du cancer et autres saloperies.. 

" Mesdames Messieurs, 
j'ai l'impression d'assister 
à une réunion syndicale 
de chauffeurs de taxis, 
AVANT l'arrivée d'Uber."

Avec les données de santé 
de 100 millions d'êtres humains on line 
(séquençage génétique, 
remontée des données de santé avec l’Internet of Things) 
on arriverait certainement à découvrir 
les processus de déclenchement 
des maladies,
C'est d'ailleurs le projet 
d'une startup chinoise 
dénommée iCarbonX. 

Un toubib m'a fait remarquer
véhémentement 
que les mauvaises compagnies d'assurances 
n'attendaient que cela, 
que les chefs d'entreprises 
seraient des plus intéressés, 
que notre système de santé 
serait ruiné.

Du grand gaulois, 
avec en arrière-plan 
le principe de précaution 
que nous avons 
dans la Constitution 
de la 5ème République.

Bref si vous voulez mon sentiment : 
un gros foutoir 1.0."

Si je n’étais pas coincé
Dans ce silo 1.zéro
J’aurai bien rigolé
Mais c’est pas de pot
Nos elites en sont toujours à des batailles d’égo
Jamais on va s’en sortir

Allez, j’aime autant en rire

J'ai sorti mon bazooka.. Je l'ai armé .. et j'ai fait feu.
Il s'en est suivi une grande confusion.. 
J'ai proposé 
à la docte assemblée 
d'expliquer comment cette santé 
prédictive 
va se mettre en place.. 
Et j'ai entendu dans le milieu de la salle 
"Non, on ne veut pas savoir »

Bref si vous voulez mon sentiment : 
un gros foutoir 1.0."

" Mesdames Messieurs, 
j'ai l'impression d'assister 
à une réunion syndicale 
de chauffeurs de taxis, 
AVANT l'arrivée d'Uber."

A force de titiller 
cette docte assemblée, 
j'ai eu enfin un éclairage 
sur notre fameux (fumeux ?) 
programme "génomique 2025" 
par un mandarin du CHU de Demain: 
On a d'abord rappelé 
l'histoire de la science génétique 
en France 
où nous étions
il y a 10-15 ans des cadors 
au niveau mondial, 
mais depuis.. 
On a rappelé
Que 2 appels d'offres 
devraient sortir incessamment 
sous peu pour démarrer ce programme .. 
que le gène BRCA1 n'est pas 
sur le chromosome 4 comme je le croyais, 
mais sur le 17.

Faites le 18
Ah non ça c’est les pompiers
Faites le 17
ça c’est le gène 
qui permet de détecter
le cancer du sein.

" Mesdames Messieurs, 
j'ai l'impression d'assister 
à une réunion syndicale 
de chauffeurs de taxis, 
AVANT l'arrivée d'Uber."

"Bref si vous voulez mon sentiment : 
un gros foutoir 1.0."

Si je n’étais pas coincé
Dans ce silo 1.zéro
J’aurai bien rigolé
Mais c’est pas de pot
Nos elites en sont toujours à des batailles d’égo
Jamais on va s’en sortir

Allez, j’aime autant en rire

On a aussi rappelé
Et que le cloud où seraient logées
nos données de santé 
serait sous l'égide du... Commissariat à l'Energie Atomique.. 
"qui s'y connaît en sécurité" 
(j'espère en tout cas 
qu'il s'y connaît en sécurité 
de centrales atomiques).
J'adore notre démocratie opaque.
Ah mon dernier Conseil : 
évitez de tomber malade ! Tenez encore 10 à15 ans … Car après …

"Bref si vous voulez mon sentiment : 
un gros foutoir 1.0."

Faites le 18
Ah non ça c’est les pompiers
Faites le 17
ça c’est le gène 
qui permet de détecter
le cancer du sein.

Faites le 18
Ah non ça c’est les pompiers
Faites le 17
ça c’est le gène 
qui permet de détecter
le cancer du sein.

"Mesdames Messieurs, 
j'ai l'impression d'assister 
à une réunion syndicale 
de chauffeurs de taxis, 
AVANT l'arrivée d'Uber."

"Bref si vous voulez mon sentiment : 
un gros foutoir 1.0."

Si je n’étais pas coincé
Dans ce silo 1.zéro
J’aurai bien rigolé
Mais c’est pas de pot
Nos elites en sont toujours à des batailles d’égo
Jamais on va s’en sortir

Allez, j’aime autant en rire.

"Mesdames Messieurs, 
j'ai l'impression d'assister 
à une réunion syndicale 
de chauffeurs de taxis, 

AVANT l'arrivée d'Uber."

"Si je n’étais pas coincé
Dans ce silo 1.zéro
J’aurai bien rigolé
Mais c’est pas de pot
Nos elites en sont toujours à des batailles d’égo
Jamais on va s’en sortir

Allez, j’aime autant en rire."