— Joachim Eeckhout (@joachimeeckhout) March 16, 2017
Affichage des articles dont le libellé est #CRISPR. Afficher tous les articles
Affichage des articles dont le libellé est #CRISPR. Afficher tous les articles
A medical thriller about CRISPR (soon out)
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| Catherine Coste |
#CRISPR Many thanks to Prof. Emmanuel Lincot & Jean-Christophe Victor for their help in writing my upcoming medical thriller, #airpocalypse pic.twitter.com/ts1ZIHeYyT— CATHERINE COSTE (@cathcoste) January 16, 2017
Le Corps du CRISPR
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| Natalie Shau |
Le corps du CRISPR
Pour Desktop Genetics
Les patients souffrant de cancer
Réclament à corps et à CRISPR
L’outil qui permet
De traiter le génome humain
Lorsque notre ADN se met
A dérailler en se recopiant à l’in-
Fini.
L’ADN se copie
Encore et encore.
Quand il y a des erreurs,
Gare au cancer !
L’ADN qui se reproduit,
Ca peut déclencher tout un tas de maladies.
On attrape le cancer
Lorsque nos cellules font des erreurs
En copiant l’ADN.
L’ADN se copie
Encore et encore.
Quand il y a des erreurs,
Gare au cancer !
L’ADN qui se reproduit,
Ca peut déclencher tout un tas de maladies.
On attrape le cancer
Lorsque nos cellules font des oh-rreurs
En copiant l’ADN.
En lisant l’ADN,
Les chercheurs
Capturent
Un gène pas très catholique
Causant, par croissance anarchique,
Des tumeurs.
Supprimer, puis réécrire un gène
Dans une cellule humaine
Pour voir comment l’organisme
Se comporte
Sans ce traumatisme,
Ce n’est pas de la tarte !
L’ADN est tout emberlificoté
Dans une microscopique cellule,
Retranché derrière deux membranes qui l’isolent.
Or voici que prendre l’ADN pour cible
Est désormais possible.
Ce n’est pas de la magie,
Plutôt de la biologie.
L’ADN a beau être entortillé
Dans une cellule microscopique
Entourée de deux parois,
Fini le désarroi.
Une nouvelle technique
Permet de supprimer, copier et coller
Des gènes en toute sérénité.
Les bactéries
Ont un système immunitaire.
Si un virus les attaque,
Elles suppriment tout à trac
L’ennemi.
Cette stratégie immunitaire,
Cette technique
100% biologique,
A été étudiée
Puis imitée
Par des scientifiques.
CRISPR est né,
C’est un outil qui permet de réécrire ou changer,
Comme vous voudrez,
L’ADN humain.
Des protéines-ciseaux capables de couper
N’importe quelle séquence d’ADN
Dans n’importe quelle cellule déterminée
Du corps humain.
Cibler l’aiguille dans la botte de foin.
Ces ciseaux moléculaires
A couper l’ADN
Sont programmés grace à des « software ».
Ces ciseaux moléculaires
S’insèrent
Dans les cellules de tout
Organisme vivant.
Avec CRISPR, vous
Coupez d’un coup de ciseaux
L’ADN des cellules can-
Céreuses.
Un gène pas catholique ?
Clac, un coup de ciseaux,
Ca lui coupe la chique
Et le cancer
Va se faire voir
Ailleurs.
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Gare !
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Si vous pensez que c’est là déraison,
Cette histoire de cancer coupé
Par des protéines-ciseaux,
C’est que vous n’avez pas encore entendu parler
De la nouvelle religion,
Le corps du CRISPR.
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Gare !
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Les cellules
Cancéreuses
Sont à présent sous contrôle.
Quels gènes causent quels
Cancers ?
Selon que ce gène-ci
Cause ce cancer-ci
Ou que ce gène-là
Cause ce cancer-là,
Le docteur ne prescrira pas
La même chimiothérapie,
Radiothérapie et caetera.
Le corps du CRISPR
Ca dit c’est comme ci
Ou c’est comme ça.
Le corps du CRISPR sera là
Pour indiquer le traitement le plus adéquat.
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Gare !
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Si vous pensez que c’est là déraison,
Cette histoire de cancer coupé
Par des protéines-ciseaux,
C’est que vous n’avez pas encore entendu parler
De la nouvelle religion,
Le corps du CRISPR.
Dans la résistance aux antibiotiques,
Un problème de santé publique
Majeur,
Utiliser CRISPR
Pour empêcher
Tout micro-organisme de résister
Aux effets des antibiotiques.
A la bonne heure,
CRISPR,
Ce drôle de loustic,
Permet de supprimer
La résistance aux antibiotiques.
Les chirurgiens dans le futur
Transplanteront des gènes
Au lieu
Des organes.
Grâce à CRISPR,
Un gène capricieux
Pourra être remplacé
Par son frère jumeau plus gracieux.
CRISPR. Couper. Coller.
Ce n’est pas de la magie,
Plutôt de la biologie.
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Gare !
CRISPR est le croisé du cancer
Qui rime avec futur.
Il va évangéliser la Terre
Plus vite que son ombre.
Si vous pensez que c’est là déraison,
Cette histoire de cancer coupé
Par des protéines-ciseaux,
C’est que vous n’avez pas encore entendu parler
De la nouvelle religion,
Le corps du CRISPR.
CRISPR. Couper. Coller.
Ce n’est pas de la magie,
Plutôt de la biologie.
CRISPR. Couper. Coller.
Ce n’est pas de la magie,
Plutôt de la biologie.
A Musical About The CRISPR Revolution In Medicine?
A #musical about #medicine? Why not Jesus #CRISPR Superstar? Got a few ideas looking for #dreamteam 2 work w/ #PWSYN pic.twitter.com/D0JkeB3QB8— CATHERINE COSTE (@cathcoste) March 26, 2016
Jesus CRISPR Superstar The Musical
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Subject: revolution in medicine, coming from diverse fields: digital, bioengineering, biology, genetics, sharing economy. |
Mocking the present health care system -- and IP, patents, DRM or digital locks, the Blockbuster Drug Quest of Big Pharma (cf. Chicago the musical)
Patients and people wanting to change things (cf Matilda the musical)
Multinationals (IBM of genomics -> Illumina) and open-access (engineers and people building platforms to cure multiple diseases, using CRISPR disease modeling. Ex: Mission Massimo, the Linux of Genomics?) and Google (23andMe -> the Google of DTC genetics) and Apple (the iPhone as your primary care physician, prescribing sensors & apps and interpreting them with algorithms).
Conventional medicine as a system where the Earth (Doctors) is placed at the center of the universe. Then comes a Doctor (pseudo: Copernicus), speaking about digital medicine, formulating a model of the universe that is placing the sun (Patients) rather than the Earth (Doctors) at the center of the universe. Disruptive! (cf. Memphis the Musical)
Writing the algorithm to cure health care system -> my body, my data.
Would you rather donate your vital organs, or your data? In organ-based medicine, it is vital that people agree to donate their organs (live organ donation, "post-mortem" organ donation). In cell-based medicine, it is vital that people consent to share their data (saving lives, just like organ donation).
Ownership of data by patient is crucial for digital medicine. In organ-based medicine, the question of ownership of medical data by patient is not relevant (patient is not a trained organ specialist). In cell-based medicine (the cell and its core, the DNA, RNA), the question of ownership of medical and genetic data by patient is becoming highly relevant.
My data on my digital device, smart because of the merge between IBM Watson and the digital device.
Empowering people: weapon of massive instruction -> MOOCs (My Kinky MOOCs, cf Kinky Boots)
Brain
Is Cell biology
Is molecular biology
Is genetics
Is a powerhouse
for microbes.
Computer science
Is medicine.
Python R Statistics MATLAB
Are tomorrow’s
Microscope
Stethoscope.
Genomics
Is making medical diagnostics.
Gene editing tool
Merry CRISPRmas
Is the new scalpel.
Left hand
Is for the wet lab
Right hand
Is for the dry lab.
Computer programmer
Is the new Doctor.
Science
Is Medicine
Is Data is data is data.
Citizen science
Is a MOOC
Is Decentralized Medicine.
Dying Steve Jobs:
« Biology and I.T. have merged.
Time to learn about it. »
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CRISPR Side Story
#CRISPR Side Story -- That #NatalieWood feeling... Boston VS California #facts #pressure #lawyerswillgetricher #IP pic.twitter.com/xxeQpSSMd1
— CATHERINE COSTE (@cathcoste) January 25, 2016
A Risky Business
Seeing ghosts? Some have tried to turn this curse into something useful...
But still, it's a risky business...
Wait. Why not try to turn this curse into... a business?...
No, I don't mean (dead) Bruce Willis helping a (cursed) little boy...
Why not try working with doctors and surgeons? If they are using outdated science, the "cursed" person working with them might see ghosts -- the dead victims of outdated science. Turning the curse/gift into some cool detector of outdated science... Organ transplant medicine could be a great place to start. Scientific polemics around "brain death", organ trafficking worldwide, shortage of organ "donation", surgeons under pressure...
Then the unexpected can happen, like some unfortunate cursed woman meeting with a gorgeous "brain-dead" ghost (not so brain-dead, actually. He was a brilliant mathematician)... Hey, that poor woman may be cursed and miserable and not so good at handling rejection, but at least she gets to choose her Bruce Willis, right?
Now this is something entirely different... The death of a young brain surgeon, his widow trying to find some rest on his grave, as she is in too much pain to be able to sleep... Would you say this woman is seeing a ghost? I don't think so. Seeing a ghost means you've never met this person before (which is aggravating the situation. Yup,there's a reason it's called a curse).
Maybe some (dead) victims of outdated science and (dead) young and brilliant scientists will somehow meet and work together on some "mad science" project? I'm curious as to the outcome of this, especially in the context of high-speed internet ghosts and a new emerging religion... Jesus-CRISPR superstar...
I told you. It's a risky business. But isn't the goal of science to remind us that no fate is destined to inevitably befall us (entropy, disease, rejection, unemployment)?
Science is averting fatalities...
But still, it's a risky business...
Wait. Why not try to turn this curse into... a business?...
No, I don't mean (dead) Bruce Willis helping a (cursed) little boy...
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Then the unexpected can happen, like some unfortunate cursed woman meeting with a gorgeous "brain-dead" ghost (not so brain-dead, actually. He was a brilliant mathematician)... Hey, that poor woman may be cursed and miserable and not so good at handling rejection, but at least she gets to choose her Bruce Willis, right?
Images of medical history...someday ones from now will look just as crazy https://t.co/5AFLC0XuSL by @erinlschumaker pic.twitter.com/RQ4uKq22CJ
— Eric Topol (@EricTopol) January 8, 2016
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| http://opinionator.blogs.nytimes.com/2016/01/06/my-marriage-didnt-end-when-i-became-a-widow |
Now this is something entirely different... The death of a young brain surgeon, his widow trying to find some rest on his grave, as she is in too much pain to be able to sleep... Would you say this woman is seeing a ghost? I don't think so. Seeing a ghost means you've never met this person before (which is aggravating the situation. Yup,there's a reason it's called a curse).
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| Burton's "Corpse Bride" |
Looking for inspiration: go no further than @rocketgirlmd https://t.co/tzOf6MQacM + https://t.co/1AubKh34Hr wow pic.twitter.com/kU3e2wjJEc
— Eric Topol (@EricTopol) January 7, 2016
I told you. It's a risky business. But isn't the goal of science to remind us that no fate is destined to inevitably befall us (entropy, disease, rejection, unemployment)?
Science is averting fatalities...
Normal Gene
Norma Jean? No, Normal Gene :-) #CRISPR https://t.co/SnIjVYBX12 #genomics pic.twitter.com/qgvEn1cwF3
— CATHERINE COSTE (@cathcoste) December 12, 2015
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| http://starsingers.net/norma-jean |
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| Two of us... And what a conundrum already... Pic |
"The Barbarian Sublimation"
If I could re-engineer myself with CRISPR, I'd definitely try to achieve this brilliant result...
Not so sure all the cool genome editing tools in the world can be helpful for this, though:
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| Link to picture (Korea) |
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| https://www.facebook.com/interestingengineering |
CRISPR, the Airpocalypse Angel
I had a dream. Chinese govt was employing armies of researchers to build #CRISPR models to understand & eradicate lung cancer #airpocalypse
— CATHERINE COSTE (@cathcoste) December 9, 2015
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| http://news.yahoo.com/chinese-dissident-artist-ai-weiwei-opens-major-london-153506388.html |
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| https://www.wacom.com/fr-fr/createmore/natalie-shau |
"No religion will ever be able to stop this"
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| A picture of me that means a lot to me. |
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| http://ethictransplantation.blogspot.fr/2011/05/quelle-religion-pourra-arreter-le.html |
I really hope that cool CRISPR-Cas 9 genome editing tool will work, sooner than later. Spoke with my friend David Kilgour today. Those atrocities are still going on...
The Two Faces of CRISPR Race
Of today's 2 NY(er/Times) #CRISPR genome editing features, 3 passages that stuck w/ me by @JenniferMKahn @specterm pic.twitter.com/XJdaHCMML3
— Eric Topol (@EricTopol) November 10, 2015
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| Eric Topol MD on twitter, Nov. 10, 2015 |
— CATHERINE COSTE (@cathcoste) November 11, 2015
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Jennifer Doudna: We can now edit our DNA. But let's do it wisely
Genetically modified humans no longer #scifi -- Geneticist Jennifer Doudna #CRISPR https://t.co/0u8a1OvtIz @TEDTalks pic.twitter.com/Ifkknq9uGF
— CATHERINE COSTE (@cathcoste) October 22, 2015
The New Yorker Festival
Feng Zhang explains how the cutting-edge gene technology CRISPR can help fight cancer: http://t.co/2jxX3GdAXk #NYerTech
— New Yorker Festival (@NewYorkerFest) October 10, 2015
"#Bio is the new digital thanks to #lifesciences #hacker mentality" - @medialab's @joi at #NYerTech @NewYorkerFest:http://t.co/2ULQL5BaJN
— CATHERINE COSTE (@cathcoste) October 16, 2015
Source: http://video.newyorker.com (Science and Tech)
From Gene Editing To Organ Transplant
RT @terryvrijenhoek: From Gene Editing To Organ Transplant http://t.co/tpkJkoYyRl @nature #SolveCure #SolveMIT pic.twitter.com/qQgV7ooAXi
— SOLVE (@SOLVE_MIT) October 7, 2015
CRISPR Technology used in organ transplant will save lives!
Hard to keep up! We're editing 1 #genomic locus @ScrippsSTSI while @geochurch edits >60 genes http://t.co/yXIrOV78sc pic.twitter.com/qxoCvIi9v6
— Eric Topol (@EricTopol) October 6, 2015
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| http://www.nature.com/news/gene-editing-record-smashed-in-pigs-1.18525 |
A quick thing on George Church's pig-editing CRISPRthon: impressive; not sure it lessens the barrier to transplants http://t.co/HtHyVI2gvh
— Ed Yong (@edyong209) October 13, 2015
“@razibkhan: Editing Pig Genomes To Grow #Transplant Organs For Humans http://t.co/KXlpYRKeNM #genetics” #CRISPR
— Robert West PhD (@westr) October 15, 2015
Editing the Human Genome
Link to article
You-On-A-Chip and You Doing Your Labs spotlighted in @FastCompany's "Innovation by Design" Oct 15 issue #indivmed pic.twitter.com/5kTOijiCBF
— Eric Topol (@EricTopol) September 15, 2015
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