Scientific MOOCs follower. Author of Airpocalypse, a techno-medical thriller (Out Summer 2017)


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


I am an early adopter of scientific MOOCs. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs? Imagine all the people sharing their data...

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Richard Bohringer: "Discard the French politicians, all of them!"

French actor and artist and writer Richard Bohringer says all politicians are useless in France (Europe?) since banks are ruling the world (not the politicians)... Richard claims he hasn't seen a single visionary leader in French politics (right-left etc.) in three decades... Well, he isn't the only one... The problem with banks is that in times of economic crisis, they play the role of the arms dealer... French banking system is on the verge of becoming as outdated as French "telcos" - France Telecom & Orange just before they got disrupted by Free, says Marc Fiorentino, ex-trader and investments specialist, Paris. In this podcast in French, he is talking on BFM Radio, a radio that specializes in economics : download audio link.


Source:
http://www.wat.tv/video/richard-bohringer-face-henri-61o15_2eyrb_.html

Dance and the City

http://www.fubiz.net/2013/03/15/dance-photography/dance-photography7/
Dance and the City, sounds as exciting as "Sex and the City", doesn't it? When I started this blog on "Ethics" some 7 years ago, I only came across sad and dull people, boring and repetitive stuff... and arrogant "specialists" (physicians) and wimpy academics who wanted me to study for some sad, dull, boring and repetitive master... Help!!! So I started this blog, 'cause to me "ethics" is all about people talking live and cash about their experience, and controversy and creativity... I started exploring ethics not only in medicine and health, but also in Google, Apple, Amazon, 3D bioprinting, politics, 2.0 (social network), startups, Big Pharma, Big Biotech Pharma, Digital Rights Management (DRM), popular TV shows and musicals, worldwide literature... and soon found out that the fun was in mixing and matching everything... How come? Well I guess it has to do with some kind of story about innovation and creativity... about Emperors and Barbarians... "Ethics" should make your heart sing, like the film "Avatar" for instance... No strident (boring and dull and repetitive) storyline... Well, this is my little discovery on this planet, and I hope you enjoy it...

What are your own genes? Something you don't own



http://mashable.com/2013/03/26/23andme/

"You Don't 'Own' Your Own Genes: Researchers Raise Alarm About Loss of Individual 'Genomic Liberty' Due to Gene Patents: "

"Just as we enter the era of personalized medicine, we are ironically living in the most restrictive age of genomics. You have to ask, how is it possible that my doctor cannot look at my DNA without being concerned about patent infringement?

The U.S. Supreme Court will review genomic patent rights in an upcoming hearing on April 15. At issue is the right of a molecular diagnostic company to claim patents not only on two key breast and ovarian cancer genes -- BRCA1 and BRCA2 -- but also on any small sequence of code within BRCA1, including a striking patent for only 15 nucleotides." (Source).

Jean-Michel Billaut (@nthropologist) :  "On pourrait dire que ce qui se passe aux USA ne nous concerne pas. Le problème c'est que les gènes des Américains sont les mêmes que les nôtres à 99,5 %... donc si un brevet mondial est pris sur le gène XXXX sur le chromosome 4, que se passe-t-il pour les Gaulois ? Les Homo Sapiens qui vivent sur le territoire américain ont 99,5% de gènes identiques aux Homo Sapiens qui vivent en Europe et en France... Comme ils sont beaucoup plus en avance que nous (désolé) ... ils vont créer des médicaments 'génétiques' pour guérir le cancer, Parkinson, etc. Médicaments que le Gaulois évolué pourra acheter sur Amazon avec 'un DRM' américain (Digital rights management)... Je ne sais pas si vous vous en rendez compte ... mais les nations dans quelques années ..." (Facebook, 27/03/2013).

Did you say "Big data"?


42: the Digital "New Deal", by Xavier Niel

French entrepreneur and businessman Xavier Niel (Free) has just launched a free programming school...

Will some physicians set up a free, embracing cultural and ideological differences think tank, no conflict of interests (?!), in order to accommodate what some people have to say to a broad public? Everybody ought to be able to have a say in this "digital world" (not only specialists talking to... specialists).

Having a meeting in France (I'm here for a short vacation) with some surgeons and doctors in my family (some of them are professional sound people; some of them are... mad). Some of them (belonging to both categories) even spoke very wisely and I couldn't agree more with what they said:

Saying in evidence...

It is a strange thing that in France (Europe?), everybody's doing his stuff on his own, hence constantly reinventing the wheel... We can hardly find a real team player over here... Scattered voices, claiming... broad public support? Will that ever work? You, me, the broad public, everybody can hardly find out about parents' real feelings regarding next-of-kin organ donation decision... Alain Tesnière, a father who has lost his son, did write some very interesting stuff, OK that was quite some time ago... and if you want to read more about those supposedly true feelings, you'll have to rely on religious websites (a German one, all about Protestantism: KAO) or on specialized books (Claire Boileau, an anthropologist: "Dans le dédale du don d'organes"). My blog can hardly be taken into account, as I am a story artist of some kind, a scenarist (fiction...)
Specialized stuff. When we're talking about feelings?...
No physician ever thought of creating some kind of think tank in order to coordinate or accommodate what people have to say to a broad public - people who, at some point in their lives, had to make a next-of-kin organ donation decision whatsoever ... To my knowledge, some French physicians have experienced this next-of-kin organ donation decision thing in their own flesh and family... How about them (or just one of them, remember the power of one...) setting up this kind of "think tank" I'm talking about? ... Or will the only echo we'll ever get to hear be Big Pharma's orchestrated speech in (forever and eternal) praise of organ "donation" (don't forget about the immuno drug money!)...
I've heard of some "ethical stuff" within public health care institution, called "Espace Ethique", but in my opinion they sound more like a bunch of wimpy academics (hardly a threat to mainstream politicians, and of course it's meant to be that way...)
Physicians in my family all think that the Doctors who provided me with some professional documents like the OPTIDO enquiry on organ donation did violate the Code of Medical Deontology.

And that such thing should never have been done... Oooops... Sure... It must have been an act of despair. Why not create some "think tank" on "the effects of organ donation" instead?...
Plus, it seems to me that family intimacy would be safer (in times of sorrow, this is of particular importance) in a think tank than on a blog or website where it would be... exposed (nobody likes that). Also, I'd be interested to hear what people have to say on 3D Bioprinting, on Health and Data...
French entrepreneur and businessman Xavier Niel (Free) has just launched a free programming school... He must be a Steve Jobs of some kind... 

My wild guess is that among French (European?) physicians, we don't have no Steve Jobs of any kind ...
Pic.

Gilles Babinet : "Everybody ought to be able to have a say in this digital world"...
 
==> Gilles Babinet : "Le plus grand nombre doit pouvoir prendre part aux opportunités de ce monde numérique". 

A grave organ shortage... aaaand a grave (brain) misunderstanding...

Is "brain death" a grave misunderstanding? 
"But Daaarling, where are you going? ..."
Why wait until death for organ donation, asks Canadian bioethicist

"More erosion of the dead donor rule in the latest issue of the Cambridge Journal of Healthcare Ethics. To the public, it probably seems axiomatic that vital organs should not removed until the donor is dead. But an increasing number of bioethicists are questioning this, especially in the light of grave organ shortages.
Walter Glennon, of the University of Calgary, breathes new life into the Epicurean argument that death does not matter: 'where death is, I am not; and where I am, death is not. So death is not to be feared, since it is nothing.'
Glennon examines the case of a severely brain-damaged patient. He argues: 'What matters is not that the donor is or is not dead, or when death is declared, but that the donor or a surrogate consents, that the donor has an irreversible condition with no hope of meaningful recovery, that procurement does not cause the donor to experience pain and suffering, and that the donor's intention is realized in a successful transplant.'
Paradoxically, he argues that doctors or relatives could actually be harming a live but brain-damaged patient if they do not allow organ donation. Harm, he says, is thwarting a person's interests. If a patient wanted to donate his organs, he would be harmed if they were not donated, or if they were unsuitable for donation because doctors waited for them to die first. 'We should reject the view that organ donors are beyond harm only after they have been declared dead and that they are harmed if organ procurement occurs before this time.'
If this is true, though, why can't people donate organs when they are well - perhaps as a way of committing suicide? Highly unlikely, Glennon responds. Such people would be irrational and hence not capable of the fundamental criterion, acting autonomously. 'It is usually the experience of an irreversible, hopeless condition that makes a person conclude that life is no longer worth living.'"

Source:  Bioedge.org

Questions hover over "brain death", says US bioethicist 

"The leading opponent of defining death as the death of the brain is D. Alan Shewmon, a professor of paediatric neurology at UCLA Medical Center. In the latest issue of the Journal of Medicine and Philosophy, an American bioethicist, E. Christian Brugger, defends him against a white paper written by the President's Council on Bioethics (PCB) in 2008.
Although the PCB was famed for its conservatism on many controversial bioethical issues and its sceptical attitude toward utilitarian reasoning, it defended the conventional standards for declaring that a patient is 'brain dead'. These are called the 'Harvard Criteria', after a 1983 paper written at Harvard Medical School. In summary, these are: unreceptivity and unresponsiveness, no movement or breathing, and no reflexes. Death was the moment 'at which the body's physiological system ceases to constitute an integrated whole'. In other words, because the brain is the integrator of all the body's systems, we know that death has occurred when these systems no longer work together.
Shewmon, however, pointed out that there are many cases in which the bodies of 'brain dead' patients - which fit the Harvard criteria - are still functioning as a whole. There have been well-documented cases of patients assimilating nutrients, fighting infections, maintaining homeostasis and body temperature, and even gestating fetuses and undergoing puberty. So, even if the brain were dead, the patients' bodies were still functioning as an integrated whole. In one astonishing case, a 'brain-dead' four-year-old boy lived on for 20 more years. He fought off serious infections and went through puberty before succumbing to pneumonia. An autopsy showed that his brain and brain stem had calcified; there were no neurons at all.
Brugger's article is too long to give an adequate summary of his doubts about the PCB's white paper. But he concludes that it failed to dismiss Shewmon's belief that the integrative capacity of a body is not located in the brain but is a property of the whole organism. If this is true, 'brain death' may not be the death of a person, only the death of an organ. 'Until these reasonable doubts are removed,' says Brugger, 'an ethically justified caution requires that we should treat them as living human beings.'"

Source:  Bioedge.org

Pic.

Stents et Data : le grand bazar bioéthique...

 WE OWN OUR HEALTH DATA. BIG PHARMA, MEDICAL ANALYSIS LABORATORIES, PHYSICIANS, PHARMACISTS DON'T.

Réglementation des dispositifs médicaux pour l'insuffisance cardiaque : les révélations d'un chirurgien... pas triste !

L'analyse très fine du système de santé français, par le Pr. Daniel Loisance, chirurgien cardiaque, Membre senior de l'Académie Nationale de Médecine, pointe les nombreux dysfonctionnements du fait de l'absence de ... données. Bricolage, approximations, travail en silos... Et cela ne vaut pas que pour les seules pathologies cardiaques. C'est l'ère de la médecine sur des post-it... Dossiers empilés, médecins hospitaliers débordés, nageant dans la paperasse (idem pour les patients). Est-ce encore de la science ? 

"Les médecins doivent avoir l'humilité de travailler sur des données, de collecter ces données ... Les moyens techniques existent aujourd'hui ; manquent les volontés pour le faire", dit le Professeur Loisance ... Les données confidentielles de nos comptes bancaires sont gérées sans aucun problème ... Commerce en ligne, achat par carte bancaire dans le monde entier ou presque, Amazonification de l'économie ... Tout cela, on sait faire ... Pourtant, on entend partout : "Les données santé (et donc leur confidentialité), c'est sacré". Faut-il mourir avec ? (tel l'Avare de Molière, qui veille sur son or) ... ou mourir ... de n'avoir pas partagé l'info (et si on l'avait fait, on aurait mieux soigné, on aurait été mieux soigné) ? Ce morcellement profite aux médecins libéraux, aux laboratoires pharmaceutiques, aux laboratoires d'analyses médicales ... bref à la médecine de papa d'hier - mais pas au patient d'aujourd'hui ... Pourtant, on veut lui fait croire le contraire (il n'est pas dupe). Les "lobbyistes" sont devenus très puissants ... et ils font du bon boulot ... Ceux qui tentent d'aller à l'encontre des schémas galvaudés (lavage de cerveau) mis en place pour que la population avale des couleuvres contraires à son intérêt sont broyés par le système, ou tout simplement ignorés (plus ou moins poliment). Cette maladie du lobbying par des conglomérats pour leurs seuls intérêts financiers (lobbying auprès des politiques et de la population) nous vient des USA ...

Data, le maître mot de la médecine de demain, qui se met en route aujourd'hui ... Big Data, Small Data... Capteurs, "sensors"... 

NOUS SOMMES LES PROPRIÉTAIRES DE NOS DONNES MÉDICALES. PAS LES PHARMACIENS NI LES LABOS PHARMACEUTIQUES NI LES LABOS D'ANALYSES MÉDICALES NI LES MÉDECINS... 

==> Être propriétaire de soi par Jacques Attali.

Les commentaires sur ce lien sont révélateurs : les gens n'ont pas d'opinion sur la question : "Est-ce nécessaire d'être propriétaire de soi ? Cela va-t-il changer le monde ?" Visiblement, ce n'est pas l'Europe qui va changer le monde ... Gros obstacles culturels (population et blouses blanches) ...

La médecine par les données ... Une révolution ... Pourtant, tout cela se prépare ... et si le chirurgien d'hier n'a pas toujours (et même rarement) su les recueillir, ces précieuses données, ni les interpréter, encore moins les utiliser, le patient de demain, lui, saura faire tout cela, à l'aide de son médecin ou chirurgien ... Il faut donc que nos aimables blouses blanches s'organisent ... L'échec d'hier (voir le lien ci-dessous) ne peut être celui de demain ... Les vendeurs de logiciels ont compris cela, déjà ... et nous concoctent ... la fin de l'univers de la santé organisé en silos ? ...

"La chirurgie cardiaque et l'évaluation des nouveaux dispositifs médicaux implantables. Audition au Sénat du Pr. Daniel Loisance, membre de l'Académie nationale de médecine, chirurgien cardiaque, ancien chef du service de chirurgie cardiaque de l'hôpital Henri-Mondor de Créteil (mai 2012)."

 ==> http://www.nossenateurs.fr/chantal-jouanno/dossier/35283

No Business Model for Digital Publishing of Books in France

Live from the Paris Book Fair March 22-25/2013:

Actually, I'm attending this book fair together with an expert in digital economics... As we are walking around and quickly exploring the various (countless) booths, we end up finding out something about e-books, eReaders, digital publishing... at the far end of the exhibition area...

The blunt truth is: there is absolutely no business model whatsoever for digital publishing of books here... The reason for this is because publishing houses (publishers 1.0) do not want to make money with e-publishing. They want to make money with paper books. Not with e-Books. I'm not sure I'd queue up for one hour (or more) just to have a copy of my favorite manga autographed...

Oh and by the way I got politely yelled at when taking this photo with my iPhone...  

"No photos of the author! No photos of the author!"

?!?... Er sorry I'm not gonna kill him... Just take some pic's for my blog... Er no my blog is NOT about porn or violence or child abuse or racial hatred... And uh... no I'm not gonna buy a copy of the Manga "Les vacances de Jésus et Bouddha" ("Saint Young Men") 'cause I travel a lot and hence need to download e-books on my eReader as much and as often as possible... I cannot afford buying loads of heavy books I 'll have to carry around with me...

I'm in touch with various authors (as a scenarist...) I've got their e-mail address and when writing to them I make sure I've got some interesting stuff for them (or at least I try to...)

So I'd rather receive an e-autograph (and a message!!!) from my favorite author... by mail or on my Facebook wall... than wait here for ages (they seem to think I need to cool my heels...), as there is so much stuff to see... and time passes so quickly... And please, Mr. Author-of-my-favorite-manga, don't mention any name ("For...") on my copy when signing it: I want to be able to sell a signed copy on Amazon for a better price... 'cause it's a signed copy ...

Of course a live chat with one's favorite author must be fascinating... But quite frankly, what can you tell to someone who has armies of "fans" waiting for him to sign their copy of his book as quick as possible, with plenty of noise all around? Nothing unforgettable, I guess... Some quick chit-chat perhaps... Probably nothing confidential or personal... Is this what books are about: superficial chit-chat? Authors should be able to set-up visio or video conferences with their fans whenever they feel they'd like to... without having to request their publisher's authorization (is that asking or begging? wait a minute: who brings the money here??). They shouldn't be prayed upon by some alleged "body guards"... They should be able to stage and do their own marketing... 'cause, pardon my French: I think that kind of marketing (see pic) sucks...

"No photos of the author! No photos of the author!"